Tumors were induced in adult and newborn rabbits by inoculation of fibroma virus. Whereas tumors completely regressed in adult rabbits by 3 weeks after virus inoculation, newborn rabbits supported tumor growth for 3 to 4 weeks. In the latter case, some animals died at this time, others survived with a gradual regression of the tumors over an additional period of 5 to 6 weeks. Virus neutralizati...

Myxoma virus (MYXV) provides an important model for investigating host-pathogen interactions. Recent studies have also highlighted how mutations in transformed human cells can expand the host range of this rabbit virus. Although virus growth depends upon interactions between virus and host proteins, the nature of these interactions is poorly understood. To address this matter, we performed smal...

This article discusses the Economic Reflections of Asean countries in facing Covid-19 Pandemic several countries, namely Vietnam, Malaysia and Indonesia. Vietnam's economic growth was victorious, economies various other Southeast Asian regions were battered by corona virus. The process is influenced two kinds factors, factors non-economic factors. which are none than production main force affec...

Abstract The host immune system has developed many mechanisms to defend against and clear virus infections, including PKR, cGAS-STING TLR-MyD88 signaling pathways. Compromised anti-viral in tumor cells allows for infection, replication lysis by oncolytic viruses. However, compromised antiviral mechanisms, together with the microenvironment (TME), limit sensitivity of cells. We generated a novel...

Current egg-based influenza vaccine production technology can't promptly meet the global demand during an influenza pandemic as shown in the 2009 H1N1 pandemic. Moreover, its manufacturing capacity would be vulnerable during pandemics caused by highly pathogenic avian influenza viruses. Therefore, vaccine production using mammalian cell technology is becoming attractive. Current influenza H5N1 ...

Virotherapy using oncolytic vaccinia virus (VACV) strains is one promising new strategy for cancer therapy. We have previously reported that oncolytic vaccinia virus strains expressing an anti-VEGF (Vascular Endothelial Growth Factor) single-chain antibody (scAb) GLAF-1 exhibited significant therapeutic efficacy for treatment of human tumor xenografts. Here, we describe the use of oncolytic vac...

The requirement of the presence of a nucleus for the replication of vesicular stomatitis virus and influenza virus has been examined by following the growth and development of these viruses in enucleate BS-C-1 cells. Vesicular stomatitis virus replicates normally in enucleate cells with the rate of production of infectious virus, the amount of virus-specific protein synthesis, and the type of p...

A system is described in which rhinovirus 2 may be grown in suspension cultures of L 132 ceils. The virus adsorbed to the cells more efficiently at 33 ° than at 4 °, probably by means of specific trypsin-sensitive lipoprotein receptors on the cells. Virus penetration demonstrated using a potent virus antiserum was temperature-sensitive and rapid at 33 ° . During single-cycle virus growth at 33 ...

Infectious Laryngotrachitis (ILT) is an acute respiratory disease with high morbidity and low mortality in poultry. ILT is caused by Gallid herpesvirus 1 (GaHV-1), a member of the Iltovirus genus and family Herpesviridae. It resulted in notable economic losses due to decreasing the growth rates, egg production, and increasing the mortality in commercial poultry, especially layer flocks, and usu...