Chronic urticaria, defined as widespread daily or nearly daily wheals for at least 6 weeks, with or without angioedema, impacts on patients’ quality of life. Natural course is self-limited, with spontaneous remissions and occasional relapses. Antihistamines, leukotriene inhibitor, immunosuppressive agents are used. 60% are idiopathic and 40% are autoimmune due to presence of anti-IgE antibody o...

Urticaria is a relatively common condition that if chronic can persist for weeks, months or years and affect quality of life significantly. The etiology is often difficult to determine, especially as it becomes chronic. Many cases of chronic urticaria are thought to be autoimmune, although there is no consensus that testing for autoimmunity alters the diagnostic or management strategies or outc...

Prieto-Lastra et al described three patients who developed adverse reactions after receiving codeine. It is known that codeine can induce direct mast cell degranulation and therefore non-IgE mediated reactions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequent cause of urticaria and patients with chronic urticaria can present worsening of symptoms with their use. One alternative for th...

BACKGROUND Avoidance behavior against positive allergens detected by using multiple allergen simultaneous test (MAST)-immunoblot assay in patients with urticaria has been rarely reported. OBJECTIVE We aimed to assess the avoidance behavior of patients with urticaria against positive allergens detected with a MAST. METHODS One hundred and one urticaria patients who showed positivity to at le...

Cold urticaria develops in response to exposure to cold stimuli, such as cold air, water or objects. Symptoms may vary from localized wheals to systemic reactions, sometimes leading to life-threatening conditions. Physicians need to be cautious when they administer cold fluid intravenously to patients who develop urticaria as a result of exposure to cold. We report here a patient in whom cold u...

INTRODUCTION Chronic urticaria is characterized by recurring episodes of spontaneous transient dermal wheals and pruritus, with or without angioedema, which can persist for ≥ 6 weeks. Chronic urticaria impairs quality of life, emphasizing the need for effective treatments. Professional societies and clinical experts have issued evidence-based recommendations for the management of chronic urtica...

Urticaria and angioedema are among the commonly encountered clinical conditions in the emergency department (ED). The severity of these conditions ranges from a simple rash to life threatening uvular edema. Recently, several studies on determining the relationship between the coagulation and inflammation markers with the acute exacerbation and severity especially on chronic urticaria patients h...

Urticaria involves intensely pruritic, raised wheals, with or without edema of the deeper cutis. It is usually a self-limited, benign reaction, but can be chronic. Rarely, it may represent serious systemic disease or a life-threatening allergic reaction. Urticaria has a lifetime prevalence of approximately 20 percent in the general population. It is caused by immunoglobulin E- and nonimmunoglob...

A previous report of two similar cases of urticaria controlled by warfarin did not include a placebo challenge.' Our case differed from those cases in that we had to keep the prothrombin time within the therapeutic range. The mechanism of this response to warfarin is obscure, but there may be a link between urticaria and the coagulation system.2-5 Ryan proposed that plasmin may contribute to ur...

BACKGROUND IgE-independent (pseudoallergic) reactions to food and food ingredients are common in a subgroup of adult patients with chronic urticaria, who have daily spontaneous occurrence of wheals. However, for children with chronic urticaria (duration longer than 6 weeks, no physical influence), no data on the importance of pseudoallergen-induced chronic urticaria are available. Therefore, we...