Tumor Therapy In article number 2106606, Nan Qin, Tiger H. Tao, and co-workers report a heterogenous silk microneedle patch to spatiotemporally sequentially deliver multiple therapeutic drugs for hemostasis, anti-angiogenesis, apoptosis of brain tumor cells. Drug release kinetics are well-defined by tuning the crosslinking degree applying trigger transcranial NIR-light irradiation. This biodegr...

Esophageal cancer is one of the most aggressive malignancies gastrointestinal tract, characterized by high malignancy potential and poor prognosis. Surgical treatment standard for localized esophageal cancer, but results only surgery locally advanced tumors remain unsatisfactory. The use neoadjuvant chemotherapy, as well chemoradiation therapy, leads to a downstaging tumor, improves its resecta...

In recent years, chimeric antigen receptor T-cell (CAR-T) therapy has made breakthroughs in the treatment of hematological tumors. However, due to different characteristics solid tumors from tumors, CAR-T not achieved good efficacy The key factors limiting mainly include tumor cells themselves and their special microenvironment (TME), which damage function multiple processes such as infiltratio...

background: recent studies in eye plaque brachytherapy have shown a considerable difference between the dosimetric results using water phantom and a model of human eye containing realistic materials. in spite of this fact, there is a lack of simulation studies based on such a model in proton therapy literatures. in the presented work, the effect of utilizing an eye model with ocular media on pr...

The lack of robust radiobiological data hampers the further optimization emerging 177Lu-PSMA-directed radioligand therapy (RLT). This study aims to explore several conventional parameters in assessment outcomes tumor and normal organs at risk (OARs) for castration-resistant prostate cancer (CRPC) patients. 20 patients received a median 3 (range 1–6, totally 86 cycles) 177Lu-PSMA-617 RLT were re...

A core–shell heterostructure consisting of plasmonic gold nanorods and porphyrinic metal–organic frameworks is synthesized as a promising platform to combine photodynamic therapy photothermal for enhanced tumor treatment.

Breast Cancer Therapy In article number 2201971, Ruibing Wang and co-workers develop supramolecular peptide (based upon the host–guest interaction between cucurbit[7]uril Phe-Phe-Val-Leu-Lys) capped Au nanocages, to allow self-aggregation into micron-sized clusters inside spermine-overexpressed tumor cells, leading specific accumulation retention of nanocages in breast for synergistic photother...

osteoid osteoma is a benign bone tumor and accounts for 10% of benign tumors. almost any bones can be involved but half of cases involving femur or tibia. osteoid osteoma is a rare tumor of the scapula with only 18 reported cases in the literature. we presented a case of osteoid osteoma of the scapula in right shoulder in angle of coracoid and geloneid in a 34- year old woman. she had right rad...

introduction: 64cu-pyruvaldehyde-bis(n4-methylthiosemicarbazone) (64cu-ptsm)‍ is one of the most important copper radiopharmaceuticals used in clinical experiments. methods: in this work, copper-64 (t1/2=12.33 h) production has been presented followed by the synthesis of the complexing agent, ptsm, and its structure was confirmed by common spectroscopic methods followed by radiolabeling with 64...

The radiobiological effects of high atomic number and energy (HZE particles) ion beams are of interest for radioprotection in space and tumor radiotherapy. Space radiation mainly consists of heavy charged particles from protons to iron ions, which is distinct from common terrestrial forms of radiation. HZE particles pose a significant cancer risk to astronauts on prolonged space missions. With ...