We examined the behavioral effects of the dietary constituents tryptophan and tyrosine on human mood, sensorimotor performance and pain sensitivity. Tryptophan and tyrosine are neurotransmitter precursors present in varying amount in protein-containing foods. Tryptophan (50 mg/kg) increased subjective drowsiness and fatigue but unlike many hypnotics did not impair sensorimotor performance. Tryp...

The Bali green banana is commonly given as additional food for babies and the elderly, because of its high nutritional value safe digestion. While Java pineapple which familiar “nanas madu” has a sweet taste rich in an active compound associated with mood. A previous study found that adult people without intermittent explosive disorder lowered serotonin bioavailability tend to selfaggressive be...

Pd-mediated C-H bond functionalisation protocols have been designed and developed on tryptophan derivatives and tryptophan-containing peptides. The examination of different arylation reactions (three sets of different conditions A-C), all of which are notable for their low temperatures (≤40 °C), allowed identification of unified and complementary synthetic approaches toward a series of function...

The stability of tryptophan, when heated in alkaline solution under conditions suitable for the hydrolysis of proteins, has been studied by a number of investigators. In general, the older reports indicate that a somewhat irregular loss of tryptophan usually occurs. With regard to the causes of this loss, the report of Lugg (l), showing that the addition of stannite resulted in partial stabiliz...

S TUDIES OF TRYPOTOPHAN metabolism in man and animals with radioactively labeled compounds require a recognition of an inherent problem related to dosages employed if meaningful quantitative data are to be gathered and analyzed. Variations in amounts of tryptophan load used could account for the lack of a sound baseline for the evaluation of results obtained in different laboratories. In the pa...

The stability of tryptophan, when heated in alkaline solution under conditions suitable for the hydrolysis of proteins, has been studied by a number of investigators. In general, the older reports indicate that a somewhat irregular loss of tryptophan usually occurs. With regard to the causes of this loss, the report of Lugg (l), showing that the addition of stannite resulted in partial stabiliz...

The concentration of 5-hydroxytryptamine (5-HT, Serotonin) varies as a result of physiological changes in the availability of its precursor tryptophan to the serotonergic neurons in the brain. Increase in brain tryptophan occurs following an increase in plasma tryptophan concentration. Tryptophan intake increases brain serotonin metabolism and enhances memory. The Present study was designed to ...

The direct electrochemical behaviour of peptide methionine sulfoxide reductase A (MsrA) adsorbed on glassy carbon and boron doped diamond electrodes surface, was studied over a wide pH range by cyclic and differential pulse voltammetry. MsrA oxidation mechanism occurs in three consecutive, pH dependent steps, corresponding to the oxidation of tyrosine, tryptophan and histidine amino acid residu...

Fluorescence of luciferases from Luciola mingrelica (single tryptophan residue, Trp-419) and Photinus pyralis (two tryptophan residues, Trp-417, Trp-426) was studied. Analysis of quenching of tryptophan fluorescence showed that the tryptophan residue conserved in all luciferases is not accessible for charged quenchers, which is explained by the presence of positively and negatively charged amin...