BACKGROUND Functional gastrointestinal disorders are common, accounting for up to 50% of gastroenterology referrals, and several randomized controlled trials have evaluated antidepressant therapy for their treatment. METHODS We performed a meta-analysis of published, English-language, randomized clinical trials on the use of antidepressants for the treatment of patients with functional gastro...

An understanding of the clinical pharmacology of antidepressant agents is essential to optimal prescribing. The following chapter outlines general principles that influence prescribing, and then discusses specific subgroups of antidepressants. There is no generally accepted classification scheme for antidepressants, and current groupings reflect marketing, the history of development, and pharma...

Antidepressants are widely used in neurological practice, and their use stroke, Alzheimer's disease, depression with cognitive impairment, Parkinson's multiple sclerosis, chronic back pain migraine is discussed. the presence of severe depressive symptoms, which observed 20–30% patients. The effect antidepressants higher case combination recurrent depression. Presence episodes before development...

BACKGROUND Antidepressant drug therapy can precipitate mania in vulnerable individuals, but little is known about the effects of age on this phenomenon. OBJECTIVE To pharmacoepidemiologically evaluate the risk of conversion to mania by antidepressant class and patient age. DESIGN, SETTING, AND PATIENTS Using an administrative national database of more than 7 million privately insured indivi...

OBJECTIVE To assess the associations between different antidepressant treatments and the rates of suicide and attempted suicide or self harm in people with depression. DESIGN Cohort study. SETTING Patients registered with UK general practices contributing data to the QResearch database. PARTICIPANTS 238,963 patients aged 20 to 64 years with a first diagnosis of depression between 1 Januar...

Major depressionis one of the most commonclinicalproblemsseen by primary-carephysicians.The prevalenceis 5% to 10% in primary-careoutpatientsand 15% in medicallyill inpatients. Despite this high prevalence rate, depression is frequently not accurately diagnosed. Evidence suggests that misdiagnosis often occurs because patients with depression frequently focus preferentially on somatic complaint...