A selective precolumn derivatization liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the determination of glucosamine in human plasma and urine has been developed and validated. Glucosamine was derivatized by o-phthalaldehyde/3-mercaptopropionic acid. Chromatographic separation was performed on a Phenomenex ODS column (150 mm×4.6 mm, 5 μm) using linear gradient elution by ...

The purpose of the study was to develop a transdermal tolterodine tartrate (TT) patch and to analyse its efficacy for overactive bladder (OAB) treatment. Patches were prepared using various polymers and plasticizers via the solvent casting method. The patches were characterized for tensile strength, thickness, moisture content, modulus of elasticity and water absorption capacity. Differential s...

It is an unspoken fact that Chinese manufacturers have been copying drugs inappropriately, despite these drugs having worldwide patent protection1, such as Abilify® (aripiprazole) for schizophrenia, depression and bipolar disorder, ALIMTA® (pemetrexed) for non-small cell lung cancer, Spiriva® (tiotropium bromide) for chronic obstructive pulmonary disorder (COPD), and Detrol® (tolterodine) for o...

Hypothesis / aims of study Several antimuscarinic agents with high-bladder selectivity have been developed and commonly used for treating overactive bladder (OAB). The problem of antimuscarinics, however, is anticholinergic-based side effects, such as dry mouth, constipation, and tachycardia, and still remains to be fully solved. Recent studies have revealed that antimuscarinic agents exert the...

10.1586/14750708.3.4.485 © 2 veractive bladder is a prevalent and debilitating condition that affects many people. rugs play a major role in treatment, together with bladder training and behavioral easures. Drugs are aimed at controlling the symptoms of overactive bladder, such as requency, nocturia, urgency and urgency incontinence, preferably with as few side effects s possible. Solifenacin i...