To design a prodrug-based self-assembling nanosystem with both ligand targeting and stimuli-responsive features, and elucidate the superiority of each targeting strategy and the synergistic effect between them, we synthesized four small molecule amphiphilic peptide-drug conjugates (APDCs) using maytansinoid (DM1) as a cytotoxic agent, cRGDfK as a homing peptide, and disulfide (SS) or thioether ...

We report a novel strategy for the controlled synthesis of gold nanoparticles (AuNPs) with narrow size distribution (1.9 ± 0.4 nm) through NP nucleation and growth inside the cavity of a well-defined three-dimensional, shape-persistent organic molecular cage. Our results show that both a well-defined cage structure and pendant thioether groups pointing inside the cavity are essential for the Au...

Thioether derivatives of tylosin and demycarosyltylosin were synthesized by Michael-type addition of thiol to C-11 of the enone moiety on the aglycone. Some of tylosin derivatives were effective to macrolide resistant Staphylococcus aureus, and their in vivo activities were same or superior than that of tylosin.

The secondary coordination ability of a paramagnetic nickel dithiolene complex, bearing an ether coordinating function within a nine-membered flexible ring, has been demonstrated in its [NiCl(DMF)(2)](+) complex, through coordination by both ether and thioether functions, allowing for a ferromagnetic interaction between both paramagnetic entities.

Appropriately-placed hydrogen bond surrogates have been demonstrated to efficiently nucleate helical conformations. Herein we describe an efficient method for the synthesis of thioether-based hydrogen bond surrogate (teHBS) helices. A teHBS helix is shown to adopt a stable conformation and target its cognate protein receptor with high affinity.

Five rare earth complexeslanthanum(III),praseodymium(III),neodymium(III), samarium(III) and europium(III) have been synthesized from Schiff base ligand (N,N-bis (2-hydroxy-1-naphthylidene) acetylhydrazone). The complexes were characterized based on elemental analysis, molar conductance, ultraviolet, infrared, mass, thermogravimetric and powder X-ray diffraction studies. Infrared spectra sug...

A new access to artemisinin is reported based on a selective photochemical hydrothiolation of amorphadiene, waste product the industrial semisynthetic route. This study highlights discovery two distinctive activation pathways under solvent-free conditions or using photocatalyst promoting H-abstraction. Subsequently, chemoselective oxidation resulting photochemically generated thioether, followe...