Anticonvulsant activity of N-(p-aminobenzoyl)-1,2,3,4-tetrahydro-4-methylquinoline (NMQ), a newly synthesized ameltolide analogue, was investigated with regards to efficacy, lethality and neurotoxicity in mice. In vivo microdialysis experiments on freely moving rats were also performed in search for the possible effect of NMQ on cortical amino acid neurotransmitters. Similar to ameltolide, intr...

Two genes in an organism have a Synthetic Sickness Lethality (SSL) interaction, if their joint deletion leads to a lower than expected fitness. Synthetic Gene Array (SGA) is a technique that helps in identifying SSL values for pairs of genes in a given set of genes. SSL interactions are useful to discover the co-expressed gene groups in the regulatory and signaling networks. Also, they are used...

Allergens are proteins and are, therefore, likely to be denatured when subjected thermal treatment. Traditional cooking has so far been able reduce allergen sensitivity by around 70–90%. This study was aimed at evaluating the effect of a broad range treatments on reduction soy immunoreactivity (IR) in 5% slurry using sandwich ELISA technique. Cooking 100 °C (10–60 min) different processing cond...

Hybrid sons between Drosophila melanogaster females and D. simulans males die as 3 instar larvae. Two genes, D. melanogaster Hybrid male rescue (Hmr) on the X chromosome, and D. simulans Lethal hybrid rescue (Lhr) on chromosome II, interact to cause this lethality. Loss-offunction mutations in either gene suppress lethality, but several pieces of evidence suggest that additional factors are req...

ATR and CHK1 maintain cancer cell survival under replication stress and inhibitors of both kinases are currently undergoing clinical trials. As ATR activity is increased after CHK1 inhibition, we hypothesized that this may indicate an increased reliance on ATR for survival. Indeed, we observe that replication stress induced by the CHK1 inhibitor AZD7762 results in replication catastrophe and ap...

TRP vanilloid 2 (TRPV2) is a nonselective cation channel expressed prominently in medium- to large-diameter sensory neurons that can be activated by extreme heat (>52°C). These features suggest that TRPV2 might be a transducer of noxious heat in vivo. TRPV2 can also be activated by hypoosmolarity or cell stretch, suggesting potential roles in mechanotransduction. To address the physiological fu...

Abstract Moringa oleifera leaves for traditional medicinal plants and as food has been widely used in Indonesia several regions the world by boiling using water a solvent before consumption. contain active compounds such phenols,flavonoids tannins. These can be helpful an antioxidant. The purpose of this study was to evaluate antioxidant activity lethality dose aqueous extract leaves. method ob...

ABSTRACT: Objectives: This study aimed to describe the incidence and proportional lethality of human leptospirosis in municipality São Paulo, between 2007 2016, according sociodemographic factors characteristics disease, assess temporal trends incidence, age group region residence. Methods: Proportional distributions cases residents were built regression models with a Binomial Negative response...

In Escherichia coli, the primosome assembly proteins, PriA, PriB, PriC, DnaT, DnaC, DnaB, and DnaG, are thought to help to restart DNA replication forks at recombinational intermediates. Redundant functions between priB and priC and synthetic lethality between priA2::kan and rep3 mutations raise the possibility that there may be multiple pathways for restarting replication forks in vivo. Herein...