Many pathophysiological phenomena are associated with soft tissue loading that does not produce visible damage or tissue failure. As such, there is an unexplained disconnect between tissue injury and detectable structural damage during loading. This study investigated the collagen fiber kinematics of the rat facet capsular ligament to identify the onset of subfailure damage during tensile loadi...

Knowledge of strain-rate sensitivity of corneal tissue is important for improving the understanding of the tissue's response to mechanical actions and the accurate numerical simulation of corneal biomechanical behaviour under the effects of disease and surgery. In the study, fresh and well-preserved porcine and ovine corneal buttons were subjected to uniaxial tension loads with seven different ...

Film coating solutions containing different grades of HPMC (E5, E15 and E50) with and without polyethylene glycol (with various molecular weights) were examined by an oscillatory method, using Haake CV 100 rheometer. Fundamental rheological parameters (?, G? and G² ) were measured over the frequency range from 0.04 to 2 Hz. The variation with frequency of the loss tangent (a ratio of viscous to...

Purpose The purpose of this study was to characterize the relation between corneal hydration and stiffening effects of the UVA/riboflavin collagen crosslinking treatment and to investigate how artificially swelling the cornea prior to this treatment procedure affects tensile property improvement. Methods Porcine corneas were collagen crosslinked in vitro at different hydration levels using a ...

By using the Carrera Unified Formulation (CUF) and a total Lagrangian approach, the unified theory of beams including geometrical nonlinearities is introduced in this paper. According to CUF, kinematics of one-dimensional structures are formulated by employing an index notation and a generalized expansion of the primary variables by arbitrary cross-section functions. Namely, in this work, lowto...

Polyphosphate (polyP) binds to fibrin(ogen) and alters fibrin structure, generating a heterogeneous network composed of 'knots' interspersed by large pores. Here we show platelet-derived polyP elicits similar structural changes in fibrin and examine the mechanism by which polyP alters fibrin structure. Polymerisation of fibrinogen with thrombin and CaCl2 was studied using spinning disk confocal...

In PG(2, q3), let π be a subplane of order q that is tangent to `∞. The tangent splash of π is defined to be the set of q2 + 1 points on `∞ that lie on a line of π. This article investigates properties of the tangent splash. We show that all tangent splashes are projectively equivalent, investigate sublines contained in a tangent splash, and consider the structure of a tangent splash in the Bru...