BACKGROUND I conducted a prospective study to assess the effectiveness of an absorbable calcium hydroxyapatite (Hac) layer mixed with vancomycin applied to the articular surface of prosthetic implants in preventing deep infections after noncemented total knee arthroplasty (TKA). This severe complication of TKA occurs in 2%-7% of cases. METHODS In all, 135 consecutive noncemented TKAs were per...

Digital dermatitis is a worldwide disease causing lameness in cattle, especially when housed. Despite its widespread nature there are relatively few peer-reviewed articles providing experimental data concerning its treatment and control. At the risk of descending to anecdote, this review attempts to summarise the current state of knowledge. Three approaches to digital dermatitis treatment have ...

Children and adolescents are subject to several periodontal diseases. Although there is a much lower prevalence of destructive periodontal diseases in children than in adults, children can develop severe forms of periodontitis. In some cases, this destructive disease is a manifestation of a known underlying systemic disease. In other young patients, the underlying cause for increased susceptibi...

IMPORTANCE Early-life antibiotic exposure has been associated with increased adiposity in animal models, mediated through the gut microbiome. Infant antibiotic exposure is common and often inappropriate. Studies of the association between infant antibiotics and childhood weight gain have reported inconsistent results. OBJECTIVE To assess the association between early-life antibiotic exposure ...

OBJECTIVE To describe the nature of bacteraemia in SLE patients and determine the short-term survival and long-term outcome of these patients. METHODS Analysis of the medical records of 1442 SLE patients who were regularly followed up in a tertiary teaching medical centre from 2000 to 2005. RESULTS Among 1442 SLE patients, 240 patients (17%) developed at least one episode of bacteraemia, co...

BACKGROUND Venous ulcers have a significant impact on patient quality of life, and constitute a worldwide public health problem. Treatment is complex, with high failure rates. OBJECTIVES To identify clinical and therapeutic factors that influence healing of venous ulcers. METHODS Retrospective cohort study of patients with venous ulcers. Ulcer area was measured at the first visit (T0) and a...

Surgical site infection (SSI) remains a significant risk for any clean orthopedic surgical procedure. Complications resulting from an SSI often require a second surgery and lengthen patient recovery time. The efficacy of antimicrobial agents delivered to combat SSI is diminished by systemic toxicity, bacterial resistance, and patient compliance to dosing schedules. We submit that development of...

OBJECTIVE To review evidence regarding antibiotic treatment of acute otitis media in children with tympanostomy tubes and to discuss antibiotic resistance and ototoxicity. QUALITY OF EVIDENCE MEDLINE, EMBASE, the Cochrane Database of Systematic Reviews, and the Cochrane Central Register of Controlled Trials were searched for relevant articles. Articles providing level I evidence(randomized co...

Discussion. We previously reported bone and fat levels some I 2 times higher than those after systemic injection (Hoddinott et al 1990) and have now extended our sampling to provide a pharmacokinetic profile over the important 24 hours after operation (Fig. 1). The results indicate that the regional intravenous administration of a single 750 mg dose of cefuroxime gave satisfactory haematoma lev...

Serum procalcitonin (PCT), which is usually produced in thyroid Ccells, is a precursor of calcitonin. In general, PCT is not released into the blood and, therefore, cannot be detected in healthy individuals [1]. However, serum procalcitonin increased significantly in response to stimulation by bacterial infections showing a favorable pharmacokinetic profile as clinical markers for bacterial inf...