Background P-selectin, expressed on the activated platelets and endothelial cells, is one of the key adhesion molecules that regulate leukocyte trafficking in atherosclerosis. The natural and canonical ligand of selectins is a specific tetrasaccharide structure known as 6-sulfo sialyl Lewis X (SLeX). Fucoidans refer to a type of polysaccharide that contains L-fucose and sulfate ester groups, ma...

Magnetic nanoparticles (MNPs) are increasingly important in magnetic resonance and biomedical optical imaging. We describe a method for imaging MNPs by detecting nanoscale displacements using a phase-resolved spectral-domain optical coherence tomography (OCT) system. Biological tissues and phantoms are exposed to approximately 800 G magnetic fields modulated at 56 and 100 Hz to mechanically act...

Introduction: To increase the radiation therapy efficiency, two approaches have been employed which include increasing the dose delivery or modifying the biological response to ionizing radiation. This study aimed to modify the biological response to ionizing radiation by combination therapy using radio-sensitizer agent and anticancer drug. Materials and Methods:</str...

E. M. Shapiro, S. Skrtic, J. M. Hill, C. E. Dunbar, A. P. Koretsky National Institutes of Health, Bethesda, MD, United States Synopsis Labeling cells with iron oxide is a useful tool for MRI based molecular and cellular imaging. Here we demonstrate, in vitro, that single, ~micron size superparamagnetic iron oxide particles can be robustly visualized with resolutions of between 50-200 microns. T...

The electron paramagnetic resonance properties of the nitric oxide derivative of liver fluke (Dicrocoelium dendriticum) hemoglobin (DD-Hb) have been investigated in the pH range from 4.8 to 7.8. In the neutral and alkaline regions the spectra have a rhombic shape, with gx = 2.09, gy = 1.99 and gz = 2.009, and a triplet hyperfine structure of 2.2 mT, due to the nitrogen of the bound NO molecule,...

The authors suggest that ultra-small paramagnetic iron oxide (USPIO) particles used as blood pool contrast agents may increase the sensitivity of midfield MRI (i.e., less than 1.5 Tesla) to physiological variations in cerebral blood volume. This hypothesis was tested on a rabbit model of apnea which increases pCO2 and cerebral blood volume. Using Sinerern as the USPIO at a blood concentration o...

A rapid and sensitive chemiluminescence microfluidic immunoassay system based on super-paramagnetic microbeads for determination of alpha-fetoprotein (AFP) is described. In this system we use CO(2) laser to fabricate microfluidic chip, and use super-paramagnetic microbeads as solid carrier of antibody, chemiluminescence as detection signal. With this system we can perform AFP analysis within 20...

iron deficiency in soil reduces the quality of durum wheat leading to fe deficiency in human. thus, this experiment investigated the effects of foliar application of nano-iron oxide (2 and 4 g l-1), iron chelate (edta), (4 and 8 g l-1), iron sulfate (4 and 8 g l-1), and the control on grain yield and quality, yield components, chlorophyll and carotenoids contents, peroxidase (pox), catalase (ca...

Objective(s): This study describes the preparation, biodistribution of 153Sm-DTPA-SPION after intravenous injection in rats. Materials and Methods: The chelator DTPA dianhydride was conjugated to SPION using a small modification of the well-known cyclic anhydride method. Conjugation was done at a 1: 4 (SPION: ccDTPA) molar ratio. Conjugation reaction was purified with magnetic assorting column...

One of the most important biological reactions of nitric oxide (nitrogen monoxide, *NO) is its reaction with transition metals, of which iron is the major target. This is confirmed by the ubiquitous formation of EPR-detectable g=2.04 signals in cells, tissues, and animals upon exposure to both exogenous and endogenous *NO. The source of the iron for these dinitrosyliron complexes (DNIC), and it...