Acute therapy with pyrimethamine plus sulfadiazine is the treatment of choice for reactivated toxoplasmic encephalitis (TE). Acute therapy is followed by lifelong maintenance therapy (secondary prophylaxis) with the same drugs at lower dosages. The use of pyrimethamine plus sulfadiazine is hampered by severe side effects including allergic reactions and hematotoxicity. Alternative treatment reg...

It has been claimed that trimethoprim, 2,4diamino 5 (3',4',5' trimethoxybenzyl)pyrimidine, exerts a "synergistic" effect when combined with sulfonamides (Hitchings, Drugs, Parasites and Hosts, p. 202, J. and A. Churchill, Ltd., London, 1962) and polymyxin (Garrod and Waterworth, J. Clin. Pathol. 15:328, 1962) in experimental infection of mice and natural 0.5 ml of a 5% suspension of granular ho...

Silver, platinum, gold, stainless-steel, and copper electrodes were used with low currents (0.02 to 20 muA/mm(2)) to explore their electrochemical effects on the growth of four bacterial species. In the higher current ranges, all electrodes inhibited growth at both poles, usually in conjunction with electrolytic break-down of the medium and severe corrosion of the metal. Silver, however, was ex...

The saprophytic bacterium Serratia plymuthica was recovered from a facial wound (burn) site of a pediatric patient. The clinical significance of the organism was undetermined due to its apparent eradication from this location by therapy with topical 1% silver sulfadiazine. Seeding of the burn with S. plymuthica may have occurred from contaminated moisture sometimes found on and around steam rad...

Even though the addition of silver sulfadiazine (AgSu) to purified deoxyribonucleic acid (DNA) results in the formation of AgSu-DNA complexes, no such complexes were detected in bacteria treated with AgSu. AgSu blocked macromolecular syntheses in treated bacteria, DNA synthesis being slightly more sensitive to this inhibitory action. The ribosomes, ribonucleic acid, and DNA isolated from treate...

Chronic wounds represent a large and growing segment of health care and add considerably to human suffering and economic burden as populations age. More effective materials, especially those promoting ease of use and economy, are needed to treat this increasing number of patients. A case series conducted at a European outpatient tertiary wound centre used a novel surfactant-based biomaterial dr...

The objective of this study was to analyze which materials and methods are used for the management of partial and full thickness burns, as well as donor sites. An Internet survey was used to poll directors of burn centers around the world on their preferences for local treatment of different types of burns and donor sites. Results were tabulated and expressed as a percentage of the total number...

The antagonism of para-aminobenzoic acid (PABA) to the chemotherapeutic action of sulfonamides in vitro and in vivo has long been established by various workers (McCarty, 1941; Selbie, 1940; Thomas and Dingle, 1942; Woods, 1940). The studies of Woods and Fildes (Fildes, 1940; Woods, 1940; Woods and Fildes, 1940) provided, furthermore, a hypothetical picture of the metabolism of bacteria, based ...