Mechanical load regulates ventricular growth, function, and structure from the earliest stages of cardiac morphogenesis through senescence. Dramatic changes in cardiac form and function have been defined for developing cardiovascular systems, and changes in mechanical loading conditions can produce structural malformations such as left heart hypoplasia. To date, relatively little is known regar...

The tail tendons from wallabies (Macropus rufogriseus) suffer creep rupture at stresses of 10 MPa or above, whereas their yield stress in a dynamic test is about 144 MPa. At stresses between 20 and 80 MPa, the time-to-rupture decreases exponentially with stress, but at 10 MPa, the lifetime is well above this exponential. For comparison, the stress on a wallaby tail tendon, when its muscle contr...

Mineralized collagen fibrils have been usually analyzed like a two-phase composite material where crystals are considered as platelets that constitute the reinforcement phase. Different models have been used to describe the elastic behavior of the material. In this work, it is shown that when Halpin-Tsai equations are applied to estimate elastic constants from typical constituent properties, no...

The objective of this paper is to explore the potential strength and serviceability implications of metallic foams, specifically steel foam, utilized as a thin-walled channel structural member. A typical advantage sought in the selection of a thin-walled member is minimal weight. However, the stability of the thin walls and the related limit states constrains the extent to which weight minimiza...

an evolutionary structural optimization (eso) method is used for plastic design of frames. based on safe theorems some criteria are derived and made an effort to satisfy them during the optimization process. in this regard, equilibrium is checked and yield condition is gradually satisfied during the optimization process. in this method, the amount of used material and the stiffness for each ele...

Recently, we reported that the stiffness of poly(dimethylsiloxane) (PDMS) affects the attachment of Pseudomonas aeruginosa, and the morphology and antibiotic susceptibility of attached cells. To further understand how P. aeruginosa responses to material stiffness during attachment, the wild-type P. aeruginosa PAO1 and several isogenic mutants were characterized for their attachment on soft and ...

In this paper, the stress distributions in carbon nanotube clamps such as those formed by the electron beam induced deposition (EBID) technique are analyzed and the contributing factors, including nanotube position, stiffness of clamp material, and thickness of the clamping pad between the AFM tip and the nanotube are examined for the case of tensile loading of the nanotube. The nanotube is mod...

Atomic force microscopy (AFM) has become a powerful tool for measuring material properties in biology and imposing mechanical boundary conditions on samples from single molecules to cells and tissues. Constant force or constant height can be maintained in an AFM experiment through feedback control of cantilever deflection, known respectively as a 'force clamp' or 'position clamp'. However, stif...