The kinetics of the signal recognition particle(SRP)-mediated process of protein translocation across the endoplasmic reticulum membrane was studied by mathematical modeling and complementary experiments. The following results were obtained. (1) A model according to which SRP directs the ribosome, rather than the mRNA, to the membrane is supported by experiments designed to discriminate between...

We have previously reported that the DsbA signal sequence promotes efficient, cotranslational translocation of the cytoplasmic protein thioredoxin-1 via the bacterial signal recognition particle (SRP) pathway. However, two commonly used signal sequences, those of PhoA and MalE, which promote export by a posttranslational mechanism, do not export thioredoxin. We proposed that this difference in ...

OBJECTIVE Periodontitis is an inflammatory condition of the supporting dental tissues that is normally treated by mechanical removal of the subgingival biofilm. This mechanical treatment, generally known as scaling and root planing (SRP), is not entirely effective, and various adjunctive therapies have been investigated to improve the clinical outcome. This study evaluated the clinical effects ...

Background: The aims of the present study were: [1] to evaluate whether Erbium-Doped: Yttrium, Aluminum and Garnet (Er: YAG) laser could be a prophylactic methods against transient bacteremia during scaling and root planing (SRP) [2] to confirm the efficacies of SRP with Er: YAG laser by clinical and microbiologic evaluations. Methods: Twenty chronic periodontitis subjects were randomly treated...

The 3'-terminal adenylic acid residue in several human small RNAs including signal recognition particle (SRP) RNA, nuclear 7SK RNA, U2 small nuclear RNA, and ribosomal 5S RNA is caused by a post-transcriptional adenylation event (Sinha, K., Gu, J., Chen, Y., and Reddy, R. (1998) J. Biol. Chem. 273, 6853-6859). Using the Alu portion of the SRP RNA as a substrate in an in vitro adenylation assay,...

OBJECTIVE Scaling and root planing (SRP) is the primary non-surgical treatment for periodontitis, but its effectiveness is limited. Consequently, various adjunctive therapies have been investigated to improve clinical outcome. This study evaluated the clinical effects of one SRP procedure alone or combined with local administration of hydrogen peroxide gel using customized trays for the treatme...

Recently,Wang et al. analyzed the security of two EPC C1-G2 compliant RFID authentication protocols, called RAPLT and SRP, and proved that these protocols are vulnerable against de-synchronization and secret disclosure attacks. The time complexity of their attacks were O(2). In addition, they proposed an improved version of SRP entitled SRP, for which they claim the security would be O(2). Howe...

This paper introduces a linear model for spacecraft formation dynamics subject to attitude-dependent solar radiation pressure (SRP) disturbance, with the SRP accounting both absorption and specular/diffuse reflection. Spacecraft attitude is represented in modified Rodriguez parameters (MRPs), which also parameterize orientation of individual facets fixed geometry. Compared earlier work, this in...

Recently,Wang et al. analyzed the security of two EPC C1-G2 compliant RFID authentication protocols, called RAPLT and SRP, and proved that these protocols are vulnerable against de-synchronization and secret disclosure attacks. The time complexity of their attacks were O(2). In addition, they proposed an improved version of SRP entitled SRP, for which they claim the security would be O(2). Howe...

In all organisms the Signal Recognition Particle (SRP), binds to signal sequences of proteins destined for secretion or membrane insertion as they emerge from translating ribosomes. In Archaea and Eucarya, the conserved ribonucleoproteic core is composed of two proteins, the accessory protein SRP19, the essential GTPase SRP54, and an evolutionarily conserved and essential SRP RNA. Through the G...