نتایج جستجو برای: sledai

تعداد نتایج: 798  

Systemic lupus erythematosus (SLE) is the most common autoimmune disease. It is characterized by the presence of hundreds of autoantibodies against many organs and tissues, including the presence of a large number of autoantibodies, which are specific to self-antigens mainly of nuclear origin such as Smith antigen, double-stranded DNA (dsDNA), anti-Sjögren’s syndrome-related antigen A and B (SS...

2014
Vinod Umare Vandana Pradhan Milind Nadkar Anjali Rajadhyaksha Manisha Patwardhan Kanjaksha K Ghosh Anita H Nadkarni

Systemic lupus erythematosus (SLE) is an inflammatory rheumatic disease characterized by production of autoantibodies and organ damage. Elevated levels of cytokines have been reported in SLE patients. In this study we have investigated the effect of proinflammatory cytokines (IL-6, TNF-α, and IL-1β) on clinical manifestations in 145 Indian SLE patients. One hundred and forty-five healthy contro...

Journal: :Rheumatology 2008
S Nakano S Morimoto J Suzuki K Nozawa H Amano Y Tokano Y Takasaki

OBJECTIVES Toll-like receptor 9 (TLR9) is a pattern-associated receptor functioning in innate immunity that may be involved in the recognition of self-antigens and the production of pathogenic auto-antibodies. Therefore, we examined the expression of TLR9 in systemic lupus erythematosus (SLE) to determine whether TLR9 is involved in the production of pathogenic auto-antibodies. METHODS B cell...

2014
Ling Zhou Guoyuan Lu Lei Shen Linfeng Wang Mingjun Wang

Our research investigates the serum levels of three angiogenic factors in the AF family, namely, placenta growth factor (PlGF), basic fibroblast growth factor (bFGF), and vascular endothelial growth factor (VEGF), in 54 patients with SLE (SLE group) and 28 healthy controls (normal control) through ELISA measurement. And their interrelationships were also systematically analyzed. The SLE patient...

Journal: :The Egyptian journal of immunology 2010
Wafaa T El-Sherif Omar M Herdan Mustafa H Osman Eman A M Alkady

Patients with systemic lupus erythematosus (SLE) have increased risk of atherosclerosis and CVD that cannot be explained by traditional risk factors. Previous studies indicated that mannose binding lectin (MBL) may modify the development of atherosclerosis. This study was designed to investigate association of MBL gene polymorphism with occurrence of preclinical atherosclerosis in SLE. The stud...

2016
Rawhya R. EL-Shereef Ahmed Lotfi Emad A. Abdel-Naeam Heba Tawfik

AIM OF THE WORK This study investigates whether serum and urinary interleukin-6 (IL-6) represent an early marker of kidney involvement and assesses the difference between them and renal biopsy in lupus nephritis (LN). PATIENTS AND METHODS A total of 60 systemic lupus erythematosus (SLE) patients were compared to 20 healthy controls. Urinary and serum IL-6 were measured in both patients and co...

Journal: :Lupus 2010
J Nossent E Kiss B Rozman G Pokorny P Vlachoyiannopoulos M Olesinska A Marchesoni M Mosca S Påi K Manger M Schneider H Nielsen R van Vollenhoven T Swaak

An inception cohort of patients with systemic lupus erythematosus from 14 European centres was followed for up to 5 years in order to describe the current early disease course. At inclusion patients (n = 200, 89% female, mean age 35 years, 97% Caucasian, mean SLEDAI 12.2) fulfilled a mean of 6.5 ACR classification criteria. The most prevalent criteria were antinuclear Ab presence (97%) followed...

2015
Sabah Alharazy Norella C. T. Kong Marlyn Mohd Shamsul A. Shah Arbaiyah Ba'in Abdul Halim Abdul Gafor

Objective. This longitudinal study aimed to determine the urine monocyte chemoattractant protein-1 (uMCP-1) levels in patients with biopsy-proven lupus nephritis (LN) at various stages of renal disease activity and to compare them to current standard markers. Methods. Patients with LN-active or inactive-had their uMCP-1 levels and standard disease activity markers measured at baseline and 2 and...

2016
Liuye Huang Yuan Yang Yu Kuang Dapeng Wei Wanyi Li Qin Yin Juan Pang Zhongwei Zhang

Objective. Systemic lupus erythematosus (SLE) is an autoimmune disease identified by a plethora of production of autoantibodies. Autoreactive T cells may play an important role in the process. Attenuated T cell vaccination (TCV) has proven to benefit some autoimmune diseases by deleting or suppressing pathogenic T cells. However, clinical evidence for TCV in SLE is still limited. Therefore, thi...

2017
Michael Mahler Chelsea Bentow Tyler O'Malley Claudia Ibarra John Conklin Mary Ann R Aure Thierry Dervieux

Objective We sought to evaluate different anti-double-stranded DNA assays for their performance characteristics in monitoring disease activity fluctuations in systemic lupus erythematosus (SLE). Methods 36 active SLE patients were followed monthly. At each study visit (total n = 371), blood was collected and disease activity was scored using the SELENA-SLEDAI (excluding anti-dsDNA or compleme...

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