it was known that il-1β-induced rapid expression of mir-146a, which regulated the secretion of inflammatory chemokines in human a549 alveolar epithelial cells. however, little is known about the level of primary mir-146a and the downstream biogenesis of mir-146a in a549 cells. we examined the levels of primary mir-146a and mature mir-146a in a549 cells following treatment with pharmacological i...

the immunopathology of sarcoidosis remains elusive despite years of research into this multiorgan disease.however, recent studies have provided new insights into the genetics and immune components involved in the clinical manifestation of the disease. granulomatous inflammation is due to the host immune response to a persistent poorly degradable unknown antigen.mycobacterium tuberculosis (mtb) ...

understanding the genetic regulatory networks, the discovery of interactions between genes, and understanding regulatory processes in a cell at the gene level, is one of the major goals of system biology and computational biology. modeling gene regulatory networks, describing the actions of the cells at the molecular level and is used in medicine and molecular biology applications such as metab...

titanium dioxide is one kind of important materials, which has been extensively investigated because of its unique electronic and optical properties. a large number of efforts have been made to synthesize tio2 materials with different methods. in this review paper, we summarize the synthesis pathways, morphology, as well as crystallization of the nanostructured tio2. in addition, we also mentio...

The Wnt signaling pathway is essential in the development and homeostasis of blood and immune cells, but its exact role is still controversial and is the subject of intense research. The malignant counterpart of normal hematopoietic cells, leukemic (stem) cells, have hijacked the Wnt pathway for their self-renewal and proliferation. Here we review the multiple ways dysregulated Wnt signaling ca...

Mitochondrial dysfunction is strongly associated with aging. A recent study shows that reduced nuclear SIRT1 activity initiates age-related mitochondrial decline through a signaling pathway that perturbs expression of genes encoded by mitochondrial DNA. This reversible pathway has potential anti-aging therapeutic value.

An impressive array of cellular and molecular adaptive responses achieves homeostasis. The inflammatory reaction is an adaptive response triggered by an insult to culminate into the overt cardinal signs of inflammation, eventually leading to resolution and returning the organism back to its original centered state. This article focuses on some aspects of the lipoxin A4 signaling pathway during ...

In systems biology, a key topic is the elucidation of the dynamic behavior of biological processes that are made up of complex biochemical networks. Statistical modeling is an important to capture the dynamics of biochemical networks such as metabolic networks, signal transduction pathways, and gene regulatory networks. These biochemical models have a set of parameters that represent the physic...