The Kv2.1 voltage-activated K+ channel, a Shab-related K+ channel isolated from rat brain, is insensitive to previously identified peptide inhibitors. We have isolated two peptides from the venom of a Chilean tarantula, G. spatulata, that inhibit the Kv2.1 K+ channel. The two peptides, hanatoxin1 (HaTx1) and hanatoxin2 (HaTx2) are unrelated in primary sequence to other K+ channel inhibitors. Th...

Voltage-gated potassium channels are critical elements in providing functional diversity in nervous systems. The diversity of voltage-gated K+ channels in modern triploblastic metazoans (such as mollusks, arthropods and vertebrates) is provided primarily by four gene subfamilies (Shaker, Shal, Shab, and Shaw), but there has been no data from the ancient diploblastic metazoans until now. Diplobl...

Snail1 and Zeb1 are E-cadherin-transcriptional repressors induced during epithelialmesenchymal-transition (EMT). In this article we have analyzed the factors controlling Zeb1 expression during EMT. In NMuMG cells treated with TGF-β, Snail1 RNA and protein are induced one hour after addition of the cytokine preceeding Zeb1 up-regulation that requires six to eight hours. Zeb1 gene expression is c...

abd- al sami’ ibn-mohammad-ali- yazdi is one of the lettered, jurists & poets of 13th century (a.h) that has done valuable services to the arabic language and literature like so many other iranian. so far, there are only a few biographical books in which he has been mentioned or introduced. unfortunately he has been forgotten during the passage of time. most of his writings are in arabic and th...

â  â  â  â  narration elements in the story of mousa and khezr â  (based on character and time) â  â  sayyed reza solayman zadeh najafi * â  azim tahmasbi ** â  â  abstract â  â  the story consists of elements such as character and time and the story features. characters make story’s structure and there is not story without character . time element is also necessary for the story . each story...

abd al-wahhab al-bayyati(1926-1999) is one of those poets whose poems make frequent use of myths. drawing on the ancient myths, and making modifications to them, he tries, while enriching his literary work, to express his views more cogently he does not simply retell the traditional myths, rather, he present new and richer interpretations of these myths and using defamiliarization, conveys his ...