BACKGROUND Sudden cardiac death (SCD), a leading cause of global mortality, most commonly arises from a substrate of cardiac ischemia, but requires an additional trigger. Diabetes mellitus (DM) predisposes to SCD even after adjusting for other DM-linked cardiovascular pathology such as coronary artery disease. We previously showed that remote liver ischemia preconditioning (RLIPC) is highly pro...

BACKGROUND Obese-insulin resistance caused by long-term high-fat diet (HFD) consumption is associated with left ventricular (LV) dysfunction and increased risk of myocardial infarction. Metformin and vildagliptin have been shown to exert cardioprotective effects. However, the effect of these drugs on the hearts under obese-insulin resistance with ischemia-reperfusion (I/R) injury is unclear. We...

Introduction: QT interval represents duration of ventricular electrical systole, i.e., the time required for completion of both ventricular depolarization and repolarization. QT interval duration normally varies between leads on the electrocardiography due to variation of repolarization and re-excitability of different ventricular regions. QT dispersion, defined as the difference between maximu...

Introduction: Studies support the idea that low levels of vitamin D are associated with a higher risk of heart disease. Losartan has also been prescribed as a drug commonly used for treating hypertension. The aim of the current study was to investigate the effects of 1,25-dihydroxyvitamin D in combination with a non-hypotensive dose of losartan on myocardial infarct size, reperfusion-induced ar...

BACKGROUND Although testosterone deficiency is associated with increased risks of heart disease, the benefits of testosterone therapy are controversial. Moreover, current understanding on the cardiac effect of testosterone during cardiac ischemia-reperfusion (I/R) periods is unclear. We tested the hypothesis that testosterone replacement attenuates the impairment of left ventricular (LV) functi...

Species-specific computer models of the heart are a novel powerful tool in studies life-threatening cardiac arrhythmias. Here, we develop such model aimed at studying infarction injury rat heart, most common experimental system to investigate effects myocardial damage. We updated Gattoni2016 cellular ionic by fitting its parameters data using population modeling approach. Using four selected mo...

RATIONALE Remote ischemic preconditioning (RIPC) has been suggested to induce cardioprotection during cardiac surgery. Maintaining proper atrial function is imperative in preventing arrhythmia and thrombus formation. Mitochondria have been proposed as key targets in conveying RIPC mechanisms and effects. MicroRNA (miR) is emerging as an important regulator of mitochondrial function, arrhythmia,...

San-Huang-Xie-Xin-Tang (SHXT) is a traditional Chinese medication consisting of three herbs, namely Coptidis rhizome, Scutellariae radix and Rhei rhizome. This study aimed to examine the cardioprotective effects of SHXT in a rat model of acute myocardial apoptosis induced by ischemia/reperfusion (I/R). Vehicle (intravenous saline) or SHXT (intravenous or oral) was administered prior to I/R (occ...

To explore the protective effect of bilobalide on pheochromocytoma cell injury induced by oxygen-glucose deprivation/reperfusion in vitro. simulate ischemia-reperfusion condition, was The cells were divided into control, and deprivation/ reperfusion+bilobalide groups. viability, proliferative capacity, malondialdehyde level, superoxide dismutase apoptosis, Wnt1 protein level nuclear beta-cateni...

OBJECTIVE To study the significance of perfusion of the infarct related coronary artery for susceptibility to ventricular tachyarrhythmias in patients with a remote myocardial infarction. SETTING Tertiary referral cardiac centre. METHODS Angiographic filling of the infarct related artery was assessed in a consecutive series of 85 patients with different susceptibilities to ventricular tachy...