The experiment sets out to investigate the effect of oxidation-reduction on nitrogen formsin soil. trial was a 3 x 2 factorial laid in Randomized Complete Block Design (RCBD) and replicated three times. Treatment consisted two variables which are poultry manure at levels (0t/ha, 6t/ha 8t/ha) water regime (field capacity waterlogged).The combinations resulted into six (6) treatments resulting po...

Hypobaric hypoxia elicits several patho-physiological manifestations, some of which are known to be lethal. Among various molecular mechanisms proposed so far, perturbation in redox state due to imbalance between radical generation and antioxidant defence is promising. These molecular events are also related to hypoxic status of cancer cells and therefore its understanding has extended clinical...

Altered metabolism constitutes a nearly universal feature of cancer cells. This metabolic reorganization in part originates from the high proliferative state displayed by cancer cells. The nature of this altered metabolism is complex with multiple strategies implemented across diverse contextual dependencies to enable the accumulation of the biomass that is necessary for proliferation in a stre...

Calcineurin (protein phosphatase 2B) (CN) comprises a family of serine/threonine phosphatases that play a pivotal role in signal transduction cascades in a variety of cells, including neutrophils. Angiotensin II (Ang II) increases both activity and de novo synthesis of CN in human neutrophils. This study focuses on the role that intracellular redox status plays in the induction of CN activity b...

Acrolein is known to be involved in acute lung injury and other pulmonary diseases. A number of studies have suggested that acrolein-induced toxic effects are associated with depletion of antioxidants, such as reduced glutathione and protein thiols, and production of reactive oxygen species. Mitochondrial NADP+-dependent isocitrate dehydrogenase (idh2) regulates mitochondrial redox balance and ...

Glioblastoma multiforme (GBM) is a highly aggressive neoplasia, prognosis remains dismal, and current therapy is mostly palliative. There are no known risk factors associated with gliomagenesis; however, it is well established that chronic inflammation in brain tissue induces oxidative stress in astrocytes and microglia. High quantities of reactive species of oxygen into the cells can react wit...