نتایج جستجو برای: radiotherapy induced diarrhea

تعداد نتایج: 1066786  

2016
Yang Chen Weishuai Liu Peng Wang Hailing Hou Ningbo Liu Linlin Gong Youyou Wang Kai Ji Lujun Zhao Ping Wang

Radiotherapy is used to treat many different human tumors. Paradoxically, radiation can activate TGF-β1 signaling and induce the epithelial-mesenchymal transition (EMT), which is associated with enhanced tumor progression. This study investigated the inhibitory effects of halofuginone, a plant-derived alkaloid that has been shown to inhibit TGF-β1 signaling, on radiation-induced EMT and explore...

2014
Vittoria Buccigrossi Gabriella Laudiero Carla Russo Erasmo Miele Morena Sofia Marina Monini Franco Maria Ruggeri Alfredo Guarino

Rotavirus (RV) infection causes watery diarrhea via multiple mechanisms, primarily chloride secretion in intestinal epithelial cell. The chloride secretion largely depends on non-structural protein 4 (NSP4) enterotoxic activity in human enterocytes through mechanisms that have not been defined. Redox imbalance is a common event in cells infected by viruses, but the role of oxidative stress in R...

2015
Kenneth W. Smith

Clinical problem and differentials. Vomiting is the forceful ejection of stomach and proximal duodenal contents through the mouth. Vomiting can be induced by vestibular, vagal, chemoreceptor trigger zone, or direct input to the emetic center. Diarrhea is a characterized by increased frequency of defecation, increased fluid content of the stool, or increased volume of stool. Markedly increased f...

2017
Nina-Sophie Hegemann Anne Schlesinger-Raab Ute Ganswindt Claudia Hörl Stephanie E Combs Dieter Hölzel Jürgen E Gschwend Christian Stief Claus Belka Jutta Engel

BACKGROUND To investigate the risk of second cancer and radiation induced second cancer following prostate cancer radiotherapy. METHODS We compared men with radiotherapy only with those treated with radical prostatectomy only and those with radiotherapy after radical prostatectomy. Cumulative incidences of second cancers were calculated. Cox analyses were performed to identify determinants in...

Journal: :The Egyptian Journal of Hospital Medicine 2021

Background: Bone is the most common site for metastases in cancer and may complicate a wide range of malignancies. Radiotherapy successful efficient method pain palliation it can prevent morbidity bone metastases. Pain flare event, occurring almost 40% patients that receive palliative radiotherapy. Dexamethasone has shown possibility prevention such flare. Objective: This study aimed to investi...

2018
Pietro Diana Charoen Mankongpaisarnrung Michael B. Atkins Jay C. Zeck Aline Charabaty

We report a 62-year-old white woman with metastatic choroidal melanoma who developed immune checkpoint inhibitor (ICI)-induced enteritis and grade 3 diarrhea refractory to steroids and infliximab. Her diarrhea quickly resolved after infusion of vedolizumab, and the patient was able to taper down steroids. Vedolizumab's mechanism of action and its gut specificity have the potential to reverse im...

2015
Michael R. Lappin

Clinical problem and differentials. Vomiting is the forceful ejection of stomach and proximal duodenal contents through the mouth. Vomiting can be induced by vestibular, vagal, chemoreceptor trigger zone, or direct input to the emetic center. Diarrhea is a characterized by increased frequency of defecation, increased fluid content of the stool, or increased volume of stool. Markedly increased f...

2013
Sutthipong Sawasvirojwong Potjanee Srimanote Varanuj Chatsudthipong Chatchai Muanprasat

Cholera is a diarrheal disease causing significant morbidity and mortality worldwide. This study aimed to establish an adult mouse model of Vibrio cholerae-induced diarrhea and to characterize its pathophysiology. Ligated ileal loops of adult mice were inoculated for 6, 9, 12 and 18 h with a classical O1 hypertoxigenic 569B strain of V. cholerae (107 CFU/loop). Time-course studies demonstrated ...

Journal: :Frontiers in bioscience 2018
Tao Wu Yang Lv Xueni Li Di Zhao Dan Yi Lei Wang Peng Li Hongbo Chen Yongqing Hou Joshua Gong Guoyao Wu

Enterotoxigenic Escherichia coli strains induce human and animal intestinal dysfunction and injury, and cause diarrhea in weanling pigs. A recombinant E.coli strain LMG194-STa which expressed single toxin STa of ETEC was constructed by directly inserting the STa gene of ETEC into the expression vector pBAD202 and then transferring the recombinant plasmid pBAD-STa into the E.coli LMG19 host stra...

2010
Zhi Yi Ong Rachel J Gibson Joanne M Bowen Andrea M Stringer Jocelyn M Darby Richard M Logan Ann SJ Yeoh Dorothy M Keefe

BACKGROUND Mucositis is a toxic side effect of anti-cancer treatments and is a major focus in cancer research. Pro-inflammatory cytokines have previously been implicated in the pathophysiology of chemotherapy-induced gastrointestinal mucositis. However, whether they play a key role in the development of radiotherapy-induced gastrointestinal mucositis is still unknown. Therefore, the aim of the ...

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