background: cationic immune stimulating complexes (pluscoms) are particulate antigen delivery systems. pluscoms consist of cationic immunostimulatory complexes (iscoms) derivatives and are able to elicit in vivo t cell responses against an antigen. objective: to evaluate the effects of pluscoms containing leishmaniamajor antigens (sla) on the type of immune response generated in the murine mode...

introduction the extended program of immunization (epi) in iran is started in 1984, and it played an important and effective role in controlling many infectious diseases in community. the objective of this study was to determine the time trends of vaccination coverage by the type of vaccine among children, in the age group of 0-24 months, in iran from the beginning of epi (1984) to 2013. materi...

lactococcus garvieae is the etiological agent of lactococcosis, an emerging disease which affects several fish species and causes important economic losses both in marine and freshwater aquaculture. lactococcosis usually happens when water temperature increases over 15°c during the year. normally, it causes a hyperacute and haemorrhagic septicemia in fish. this paper presents a procedure for pr...

human papilloma virus (hpv) vaccine recently has been added to the iran drug list, decision makers need information beyond that available from rcts to recommend funding for this vaccination program to add it to the national immunization program in iran. modeling and economic studies have addressed some of those information needs in foreign countries. in order to determine the long term benefit ...

background: hepatitis c virus (hcv) infection is one of the most prevalent infectious diseases responsible for high morbidity and mortality worldwide. therefore, designing new and effective therapeutics is of great importance. the aim of the current study was to construct a dna vaccine containing structural proteins of hcv and evaluation of its expression in a eukaryotic system. methods: struct...

background: tuberculosis (tb) remains as a major cause of death around the world. construction of a new vaccine against tuberculosis is an effective way to control it. several vaccines against this disease have been developed. the aim of the present study was to cloning of tb10.4 gene in pcdna3.1+ plasmid and evaluation of its expression in eukaryotic cells. methods: firstly, tb10.4 fragment wa...

Background & Objective: DNA vaccines as a new generation of vaccines require adjuvant to improve vaccine immunogenicity; adjuvants can also increase the DNA vaccine efficacy. In this study, the effects of the host’s interferon-inducible Mx protein as bio adjuvant and conventional alum adjuvant were evaluated.   Materials & Methods: The BALB/c mice were immunized by different prime-boost strate...