Abstract: Aim: The present work intends to formulate and evaluate film forming solution of diphenhydramine. Materials Methods: Film solutions (FFS) for transdermal delivery Diphenhydramine HCl were prepared using different polymers (hydroxypropyl cellulose, Eudragit L 100, polyvinylpyrollidone K30 K90), PEG 400 as plasticizer ethyl alcohol solvent. Results: found display an acceptable drying ti...

in this work we sought to determine whether vesicles (liposomes/niosomes) were able to enhance finasteride concentration in the dermis layer, including the pilosebaceous units (psu). such enhancement could be beneficial in the treatment of some androgen-related skin disorders. hamster flank skin was used to study  3hfinasteride permeation via vesicles and a hydroalcoholic solution (ha). the dru...

Although permeation of hydrocarbons such as Benzene, Toluene, Ethybenzene, and Xylene (BTEX) through polyethylene (PE) pipe in potable water applications is rarely occurred. It is important to understand permeation mechanism and characterize the potential health risk. The most common potential hydrocarbon substances are originated from gasoline leaks. Previous research has shown that pipe mater...

Abstract: Terbinafine HCl is an allylamine used to treat fungal infections. It has substantial side effects that can be mitigated by using a topical semisolid dose form. The objective of this study was develop 1% film-forming spray formulation developed combining polymers, penetration enhancer, plasticizer, and suitable solvent system. central composite design with 3 independent variables 2 dep...

Summary: Low frequency ultrasound in combination with Sodium Lauryl Sulphate (SLS), a known transdermal chemical enhancer has been found to enhance delivery of molecules through the skin. In this abstract, we report the effects of changing SLS concentration on cavitation, protein permeation through the skin and skin damage. Introduction: Low-frequency ultrasound (US), applied to skin via a liqu...

Innovative Nano-carrier-based transdermal patches, a wonder of advanced technologies, have received overwhelming endorsement in medicinal applications primarily the provision anti-neoplastic drugs. The purpose this study was to review limitations conventional therapeutic initiatives namely chemotherapy, having several adverse effects, including significant inflammation, toxicity, and discomfort...

comNode classification within Membrane Residue Curves (M-RCMs) currently hinges on Lyapunov’s Theorem and therefore the computation of mathematically complex eigenvalues. This paper presents an alternative criterion for the classification of nodes within M-RCMs based on the total membrane flux at node compositions. This paper demonstrates that for a system exhibiting simple permeation behaviour...

drug administration. However, the barrier properties of the outermost layer, the stratum corneum, have limited the number of successful transdermal dosage forms developed thus far. One of the strategies for overcoming this problem is temporary local reduction of the barrier function of the stratum corneum with the aid of a percutaneous absorption enhancer. Sucrose fatty acid esters (sugar ester...