نتایج جستجو برای: parenteral opioid drugs
تعداد نتایج: 263494 فیلتر نتایج به سال:
STUDY OBJECTIVES The effect of opioid medications on sleep architecture has been demonstrated in patients with comorbid pain or opioid addiction. This study examined whether commonly used opioid medications have an adverse effect on sleep architecture in healthy adults. METHODS Forty-two healthy subjects were examined with polysomnography after a bedtime dose of placebo, sustained-release mor...
Intravenous (i.v.) administration of antiepileptic drugs (AEDs) produces the most rapid onset of action, as it is delivered directly into the bloodstream and immediately produces maximal plasma concentration (C0 = Cmax). In addition to its therapeutic value, i.v. administration is essential in investigating the pharmacokinetics (PK) or clinical pharmacology of drugs, as it bypasses absorption a...
Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared by coupling the molecular features of two wellknown drugs, ie, rimonabant and fentanyl. The new compounds have been tested for their affinity and functionality regarding CB1 a...
Prospective, Randomized Comparison of Epidural Versus Parenteral Opioid Analgesia in Thoracic Trauma
PURPOSE The goal of these studies was to determine the relationship between prescribed use of opioid analgesics and their non-medically related use (abuse) at a regional level across the country. METHODS To gather information about prescription drug abuse, we asked 233 drug abuse treatment specialists to provide us Quarterly reports on the number of cases of prescription opioid analgesic abus...
Inflammation enhances the peripheral analgesic efficacy of opioid drugs, but the mechanisms involved in this phenomenon have not been fully elucidated. Crotalphine (CRP), a peptide that was first isolated from South American rattlesnake C.d. terrificus venom, induces a potent and long-lasting anti-nociceptive effect that is mediated by the activation of peripheral opioid receptors. Because the ...
Background: A number of drugs are used to control opioid withdrawal symptoms during detoxification. Tramadol, as a partial opioid agonist, has been widely used to manage acute and chronic pains. The present study was designed to assess the effectiveness of tramadol in methadone-assisted detoxification. Methods: In a double-blind randomized clinical trial 72 opioid-dependent patients as defined ...
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