نتایج جستجو برای: parenteral opioid drugs

تعداد نتایج: 263494  

Journal: :Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2007
Joel E Dimsdale Daniel Norman Douglas DeJardin Mark S Wallace

STUDY OBJECTIVES The effect of opioid medications on sleep architecture has been demonstrated in patients with comorbid pain or opioid addiction. This study examined whether commonly used opioid medications have an adverse effect on sleep architecture in healthy adults. METHODS Forty-two healthy subjects were examined with polysomnography after a bedtime dose of placebo, sustained-release mor...

Journal: :Epilepsia 2007
Meir Bialer

Intravenous (i.v.) administration of antiepileptic drugs (AEDs) produces the most rapid onset of action, as it is delivered directly into the bloodstream and immediately produces maximal plasma concentration (C0 = Cmax). In addition to its therapeutic value, i.v. administration is essential in investigating the pharmacokinetics (PK) or clinical pharmacology of drugs, as it bypasses absorption a...

Journal: :International Journal of Pharmaceutics 1991

2014
Cristina Fernández-Fernández Luis F Callado Rocío Girón Eva Sánchez Amaia M Erdozain José Antonio López-Moreno Paula Morales Fernando Rodríguez de Fonseca Javier Fernández-Ruiz Pilar Goya J Javier Meana M Isabel Martín Nadine Jagerovic

Based on numerous pharmacological studies that have revealed an interaction between cannabinoid and opioid systems at the molecular, neurochemical, and behavioral levels, a new series of hybrid molecules has been prepared by coupling the molecular features of two wellknown drugs, ie, rimonabant and fentanyl. The new compounds have been tested for their affinity and functionality regarding CB1 a...

Journal: :Current Opinion in Solid State and Materials Science 2012

Journal: :Pharmacoepidemiology and drug safety 2007
Theodore J Cicero Hilary Surratt James A Inciardi Alvaro Munoz

PURPOSE The goal of these studies was to determine the relationship between prescribed use of opioid analgesics and their non-medically related use (abuse) at a regional level across the country. METHODS To gather information about prescription drug abuse, we asked 233 drug abuse treatment specialists to provide us Quarterly reports on the number of cases of prescription opioid analgesic abus...

2014
Vanessa Olzon Zambelli Ana Carolina de Oliveira Fernandes Vanessa Pacciari Gutierrez Julio Cesar Batista Ferreira Carlos Amilcar Parada Daria Mochly-Rosen Yara Cury

Inflammation enhances the peripheral analgesic efficacy of opioid drugs, but the mechanisms involved in this phenomenon have not been fully elucidated. Crotalphine (CRP), a peptide that was first isolated from South American rattlesnake C.d. terrificus venom, induces a potent and long-lasting anti-nociceptive effect that is mediated by the activation of peripheral opioid receptors. Because the ...

M. Amanatkar M. Salehi, Majid Barekatain

Background: A number of drugs are used to control opioid withdrawal symptoms during detoxification. Tramadol, as a partial opioid agonist, has been widely used to manage acute and chronic pains. The present study was designed to assess the effectiveness of tramadol in methadone-assisted detoxification. Methods: In a double-blind randomized clinical trial 72 opioid-dependent patients as defined ...

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