Chronic kidney disease (CKD) is a worldwide health problem. Serum levels of FGF23, a phosphaturic hormone, increase at the earliest stages of CKD, and have been found to be independently associated with the mortality and morbidity of CKD patients. The purpose of this study was to evaluate whether FGF23 neutralization was able to improve bone quality and osseointegration of titanium implants. Ur...

INTRODUCTION: Osseointegration is crucial for early fixation as well as long-term success of orthopaedic implants. Contaminants, such as bacterial debris and manufacturing residues, can remain on an implant surface after sterilization procedures and inhibit osseointegration [1]. Bacterial debris contains pathogen associated molecular patterns (PAMPs), which are molecular motifs that activate th...

In vivo implants that are composed of titanium and titanium alloys as raw materials are widely used in the fields of biology and medicine. In the field of dental medicine, titanium is considered to be an ideal dental implant material. Good osseointegration and soft tissue closure are the foundation for the success of dental implants. Therefore, the enhancement of the osseointegration and antiba...

BACKGROUND Growth factor-containing products have been reported to increase implant stability and accelerate osseointegration. Concentrated growth factor (CGF) can be used for this purpose with the growth factors it contains. The aim of this study is to assess the effect of CGF on implant stability and osseointegration. METHODS Twelve patients with maxillary anterior toothless were included i...

A growing number of clinical studies show that early (2 months) and immediate loading protocols may be predictable. However, they are based on clinical stability only The aim of this case report was to document the osseointegration status of two Osseotite implants after 2 months of healing in soft bone corresponding to type IV and subjected to two distinct mechanical environments. A completely ...

During the past two decades, dental implants have been used extensively to achieve osseointergration for prosthetic rehabilitation of edentulism. For this, a surgical procedure is performed on patient to insert a foreign material i.e implant into the bone, after which a poorly organized woven bone is formed at the interface, thus having a relatively low inherent strength. After a period of 3 to...

Titanium implants are widely used in dental clinics and orthopaedic surgery. However, bone formation surrounding the implant is relatively slow after inserting the implant. The current study assessed the effects of bone marrow stromal cells (BMSCs) with forced expression of special AT-rich sequence-binding protein 2 (SATB2) on the osseointegration of titanium implants. To determine whether SATB...

The high success rates for the dental rehabilitation of patients with endosseous implants have resulted from many research approaches with the aim of enhancing and accelerating bone anchorage to the implant, thereby providing optimal support for the intraoral prosthetic devices. This revolutionary breakthrough has first evolved from the research efforts of the Brånemark group in the late 1960s ...

The circadian rhythm regulates many physiological human health and disease processes. central clock is located in the suprachiasmatic nucleus hypothalamus controls a whole range of genes. During bone remodeling, gene expression was observed osteoblasts osteoclasts. Moreover, genes are an essential part network osseointegration titanium implants. Namely, biomaterials significantly affect oral ca...

The successful use of surgical and medical methods jaw bone tissue restoration has been convincingly confirmed in clinical practice. At the same time, technologies are being developed to improve osseointegration dental implants patients with osteoporosis. various implant coatings, as well systemic therapy, demonstrate emergence new directions treatment partial or complete secondary edentulism c...