background and aims. the aim of the present study is to determine the incidence of mthfr c677 t and a1298c mutations in iranian patients with cleft lip and/or cleft palate. materials and methods. we screened 61 iranian patients with cleft lip and/or cleft palate for mutations in the two alleles of mthfr gene associated with cleft lip and/or palate: a1298c and c677t, using polymerase chain react...

objective: crocin and safranal are the main components of saffron, and have many biological functions such as anti-inflammatory and antioxidant activities. in the present study, we investigated the effects of crocin, safranal, morphine, diclofenac and naloxone in combined and separately on formalin-induced orofacial pain in rats. materials and methods: subcutaneous injection of a diluted formal...

Cheilitis granulomatosa is characterized by granulomatous lip swelling. We report a case of a 13-year-old girl who presented with orofacial swelling and arthralgia, who eventually was diagnosed with Crohn's disease, which was successfully treated with infliximab and azathioprine combination therapy. Recurrent or persistent orofacial swelling should prompt consideration of cheilitis granulomatos...

in the present study, the effects of intra-hippocampal microinjections of morphine (an opioid agonist) and naloxone (an opioid antagonist) were investigated in the formalin-induced orofacial pain in rats. orofacial pain was induced by subcutaneous injection of formalin (1 %, 50 μl) in the upper lip region and the time spent of face rubbing was measured in 3-min blocks for 45 min. formalin induc...

objectives: crocin, a constituent of saffron and yellow gardenia, possesses anti-nociceptive effects. in the present study, we investigated the effects of intra-fourth ventricle injection of crocin in a rat model of orofacial pain. the contribution of opioid system was assessed using intra-fourth ventricle injection of naloxone, an opioid receptor antagonist. materials and methods: a guide cann...

Scleroderma (skleros; hard, and derma; skin), is currently known as systemic sclerosis due to its progressive nature and widespread tissue involvement. It is a rare connective tissue disorder with a wide range of oral manifestations. Thickening of the skin is the hallmark of the disease. The patient education for self-care and multidisciplinary approach would be needed to manage the condition. ...

Introduction: Orofacial clefts are among the most common congenital anomalies. Patients presenting with orofacial clefts often require surgery or other complex procedures. A cleft lip or palate can be a single anomaly or a part of multiple congenital anomalies. The reported prevalence of cleft disease and associated anomalies varies widely across the literature, and is dependent on the diagnost...

OBJECTIVES To analyze the frequency and type of benign orofacial lesions submitted for diagnosis at Tripoli Medical Centre over 17 years period (1997-2013). MATERIALS AND METHODS Entries for specimens from patients were retrieved and compiled into 9 diagnostic categories and 82 diagnoses. RESULTS During the 17 years period, a total of 975 specimens were evaluated, it comprised a male-female...