Although oral submucous fibrosis (OSF) is the most common precancerous lesion of the oral cavity in Southeast Asia where the habit of betel quid (BQ) chewing is popular, its molecular biological properties are largely unknown. The aim of this study was to identify the genes responsible for its pathogenesis and malignant transformation using oligonucleotide microarray. The expression profiles of...

BACKGROUND Evaluation of molecular pathology markers using a computer-aided quantitative assessment framework would help to assess the altered states of cellular proliferation, hypoxia, and neoangiogenesis in oral submucous fibrosis and could improve diagnostic interpretation in gauging its malignant potentiality. METHODS Immunohistochemical (IHC) expression of c-Myc, hypoxia-inducible factor...

AIM To study, whether the consumption of regular tea/coffee (methylxanthines) increases the risk of oral cancer in patients with smoking and smokeless tobacco habits. MATERIALS AND METHODS This study was conducted on a total of 90 oral cancer and precancerous patients, from western Maharashtra (India) males in the age group of 20 to 45 years who were with smoking and smokeless tobacco habits;...

OBJECTIVES To determine the prevalence of leukoplakia, oral submucous fibrosis and papilloma among "Green Marble Mines" laborer and uncover its relation with occupational stress. METHODS Mines were divided in four geographic zones, and participants were selected by stratified cluster sampling technique. A total of 513 subjects were included in final study which were alienated among the four a...

The Harvard community has made this article openly available. Please share how this access benefits you. Your story matters. ABSTRACT www.scielo.br/jaos O bjectives: Oral cancer (OC) may be preceded by clinically evident oral potentially malignant disorders (OPMDs). Oral carcinogenesis is a multistep process that begins DV HSLWKHOLDO K\SHUSODVLD DQG SURJUHVVHV WR RUDO HSLWKHOLDO G\VSODVLD DQG ¿...

The incidence and prevalence of oral precancerous conditions and lesions is very high in various parts of India, especially Central India. Most commonly seen oral pre cancerous conditions here include oral submucous fibrosis (OSMF), leukoplakia, oral lichen planus (OLP) and erythroleukoplakia. Facts and figures about these conditions such as aetiology, clinical features, signs and symptoms, sta...

Aim and Objectives. Oral submucous fibrosis (OSF) is a potentially malignant disorder associated with the usage of areca nut. Usage of processed forms of areca nut is popular among the youth and its carcinogenic effects are not well known. Due to large immigrant population, various patterns of areca nut usage are seen. The aim of this study is to assess the various quid chewing patterns and the...