Oxycodone is a valued opioid analgesic, which may be administered either as the first strong opioid or when other strong opioids are ineffective. In case of insufficient analgesia and/or intense adverse effects such as sedation, hallucinations and nausea/vomiting a switch from another opioid to oxycodone might be beneficial. Oxycodone is administered to opioid-naive patients with severe pain an...

In recent years, an increasingly detailed picture of gastrointestinal dysfunction in the setting of Parkinson's disease has emerged. Abnormalities of function may occur at virtually all levels of the gastrointestinal tract. Weight loss, dental deterioration, salivary excess, dysphagia, gastroparesis, decreased bowel movement frequency, and anorectal dysfunction all may occur. The pathophysiolog...

Evidence exists of an increased risk of irritable bowel syndrome after an episode of bacterial gastroenteritis. 2 In one study, 12 out of 38 patients presented with bowel dysfunction 1 year after salmonella gastroenteritis. In another study, 386 patients with bacterial gastroenteritis were surveyed by questionnaire 6 months after infection, and 27 (7%) had developed irritable bowel syndrome. Bo...

PURPOSE Bladder, bowel and sexual dysfunction are often overlooked symptoms in patients with multiple sclerosis (MS) and can be associated with lower health-related quality of life (HRQoL). The aim is to explore the association of bladder, bowel and sexual dysfunction with HRQoL in MS patients stratified by disease duration (≤5 and >5 years) and controlled for clinical and sociodemographic vari...

External exposed radiation may play an important role in pathogens of irritable bowel syndrome (IBS), although is thought to arise due to a combination of genetic and environmental factors. The result is dysregulated immune responses due to alteration in the gut microbiota population and the subsequent development of gut inflammation. It has recently been shown that the effect of ioni...

Objective: <i>Jowiseunggi-tang</i> (JWSGT) is a traditional herbal medicine commonly used for purgative activity in constipation. This study evaluates JWSGT the treatment of opioid-induced constipation (OIC), most common and debilitating gastrointestinal effect opioid use.Methods: A 64-year-old man with floor mouth cancer was hospitalized OIC, administered orally twice day 10 days, ...