نتایج جستجو برای: nucleic acid sequence based amplification
تعداد نتایج: 3885413 فیلتر نتایج به سال:
Using an amplified single molecule detection platform based on padlock probe and proximity ligation, detection of very low amounts of nucleic acid or protein molecules is achieved. Protein and nucleic acid analyses are performed in a similar fashion using circularizing DNA probes, rolling circle amplification and fluorescence-based counting of single reporter molecules. This allows a single sys...
INTRODUCTION The aim of the study was to evaluate the clinical usefulness of a one-step nucleic acid amplification assay (OSNA) for intraoperative detection of metastases to sentinel lymph nodes (SLNs) in comparison to examination of frozen sections, and to summarize the results of previous studies. MATERIAL AND METHODS We enrolled 98 patients aged 58.13 ±10.74 years treated surgically for br...
On the basis of the distance-dependence of DNA-templated reductive amination reactions and of recent findings of D. Lynn and co-workers, we developed DNA-templated polymerizations of synthetic peptide nucleic acid (PNA) aldehydes. The coupling reactions proceed in a highly efficient and sequence-specific manner, even in the presence of mixtures of PNA aldehydes of different sequence. Synthetic ...
Received: Revised: Accepted: 2014–05–26 2014–07–14 2014–07–15 Disease diagnosis is of crucial importance in making appropriate therapeutic decisions. Conventionally, diagnosis was based on isolation and identification of the causative agent. This was followed in timeline by the development of serological tests. Nowadays, molecular tests credited with high sensitivity like polymerase chain react...
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