Background: To understand the role of sporadic mutations in the tumor suppressor gene p53 (also known as TP53) in the pathogenesis of breast cancer, it is important to identify at which histologic stage such mutations first occur. We previously showed that a p53 mutation present in invasive breast cancer was found in all surrounding areas of ductal carcinoma in situ (DCIS) but not in areas of h...

The estimation of energy uses and corresponding greenhouse gas emissions (GHG) from the nuclear energy chain by Storm van Leeuwen J.W. and Smith P. (last available version: SvLS 2005) is often quoted especially by nuclear opponents who question the characteristic of nuclear energy to be near GHG-free. SvLS guesstimate relatively high to very high energy requirements and hence corresponding CO2 ...

BACKGROUND To understand the role of sporadic mutations in the tumor suppressor gene p53 (also known as TP53) in the pathogenesis of breast cancer, it is important to identify at which histologic stage such mutations first occur. We previously showed that a p53 mutation present in invasive breast cancer was found in all surrounding areas of ductal carcinoma in situ (DCIS) but not in areas of hy...

in the open-pit mining, one of the first decisions that must be made in production planning stage, after completing the design of final pit limits, is determining of the processing plant cut-off grade. since this grade has an essential effect on operations, choosing the optimum cut-off grade is of considerable importance. different goals may be used for determining optimum cut-off grade. one of...