Background: Biochemical and biophysical factors jointly regulate the cellular dynamics in many physiological processes. It is therefore imperative to include multiplexed microenvironment cues when employing in vitro cell-based assays model processes. Methods: To meet this need, we have developed a modular p...

Introduction: This report describes the use of conjunctival flaps to enable survival type I keratoprosthesis (KPro) in two cases bilateral severe total limbal stem cell deficiency (LSCD) following chemical burns. Presentation case: Two patients had a history injury with lime. On examination, presenting...

Background: Adequate staffing is key to the delivery of nursing care and thus improved inpatient health service outcomes. Several systematic reviews have addressed relationship between nurse these Most primary studies within each review are likely be from high-income countries which different practice contexts low middle-income (LMICs), although this has not been for...

Hepatitis C virus (HCV) helicase, non-structural protein 3 (NS3), is proposed to aid in HCV genome replication and is considered a target for inhibition of HCV. In order to investigate the substrate requirements for nucleic acid unwinding by NS3, substrates were prepared by annealing a 30mer oligonucleotide to a 15mer. The resulting 15 bp duplex contained a single-stranded DNA overhang of 15 nt...

Background: Trypanosoma brucei is a protozoan parasite and etiological agent of human animal African trypanosomiasis. It has complex life cycle, but the most studied cellular types are in vitro cultivated bloodstream- procyclic-forms. These correspond to replicating, mammalian host bloodstream...

Background Despite advances in the quality of acute stroke management, there are gaps knowledge about effective support interventions to better manage transition care home for patients with this complex condition. The goal systematic review is explore literature around available as they navigate from hospital, rehabilitation or early supported discharg...

Background: The Republic of Mauritius had a total 422,567 disability-adjusted life years (DALYs) from all causes in 2019. This study aimed to estimate the monetary value DALYs lost 2019 and those projected to be 2030; savings 2030 if were attain national targets related five United Nations Sustainable Development Goal 3 on good health well-being....

Background: Extreme poverty can result in people barely surviving with poor living standards to the extent of on streets, often fear. With limited access healthcare services and a clean environment, they are more vulnerable life adversities. Highly stressful conditions like these cause mental illnesses such as depressive disorders, anxiety psychological distress, oth...

The flavivirus nonstructural protein 3 (NS3) bears multiple enzymatic activities and represents an attractive target for antiviral intervention. NS3 contains the viral serine protease at the N-terminus and ATPase, RTPase, and helicase activities at the C-terminus. These activities are essential for viral replication; however, the biological role of RNA remodeling by NS3 helicase during the vira...

Background: Excessive trace element exposure has been linked to a variety of harmful health impacts. The goal this study was track the amounts several elements in boneless whole chicken samples collected from various shops Amman, Jordan. Methods: Using inductively coupled plasma-optical emission spectroscopy (ICP-OES), 30 were and ...