clinicians should be aware of new developments to familiarize themselves with pharmacokinetic and pharmacodynamic characteristics of new anticoagulant agents to appropriately and safely use them. for the moment, cardiologists and other clinicians also require to master currently available drugs, realizing the mechanism of action, side effects, and laboratory monitoring to measure their anticoag...

background: warfarin is an effective oral anticoagulant which exert its effect by blocking the utilization of vitamin k. warfarin therapy requires ongoing monitoring using the international normalized ratio (inr). in this study, effect of modest increase in vitamin k intake from vegetables on inr values was evaluated in warfarin treated patients. methods: a single-center study involving 24 outp...

The risk of idiosyncratic drug toxicity (IDT) is of great concern to the pharmaceutical industry. Current hypotheses based on retrospective studies suggest that the occurrence of IDT is related to covalent binding and daily dose. We determined the covalent binding of 42 radiolabeled drugs in three test systems (human liver microsomes and hepatocytes in vitro and rat liver in vivo) to assess the...

Abstract The distance matrix

written for a particular gain. Then KGH = −1 so that a) when the amplitude of KGH is 1 or 0 dB and b) phase is 180o then we have the system just become unstable. Both the conditions have to be fulfilled. Hence, if we ask the question: How far is the system from instability ? We get two answers. The gain increment required at the frequency where phase is 180o and the phase increment required at ...

The capability of the dimensions measurement by ten appraisers of ten samples for Charpy Vnotch pendulum impact test was evaluated by Youden plot, analysis of measurement uncertainties, Measurement Systems Analysis (MSA), %P/T, Z-score, Mandel’s statistics and ttest. The group of “better” appraisers given by Youden plot was validated by majority of other methods.

In response to my analysis of the Wellstone tragedy (READER WEEKLY, 28 November 2002, pp. 18-19) and related discussion of this event, I have received quite a few emails, many of which have taken strong exception to the very idea that George W. Bush could ever have been involved in something of this kind. My suggestion that Republicans may have been motivated to take Wellstone out, alas, is not...

A graphics package has been developed to display the main chain torsion angles phi, psi (phi, Psi); (Ramachandran angles) in a protein of known structure. In addition, the package calculates the Ramachandran angles at the central residue in the stretch of three amino acids having specified the flanking residue types. The package displays the Ramachandran angles along with a detailed analysis ou...

As the frequency and size of wildfires increase, accurate assessment burn severity is essential for understanding fire effects evaluating post-fire vegetation impacts. Remotely-sensed imagery allows rapid severity, but it also needs to be field validated. Permanent forest inventory plots can provide information validation remotely-sensed metrics, although there often a mismatch between shape pl...