To construct an auto-tissue-engineered lamellar cornea (ATELC) for transplantation, based on acellular porcine corneal stroma and autologous corneal limbal explants, a dynamic culture process, which composed of a submersion culture, a perfusion culture and a dynamic air-liquid interface culture, was performed using appropriate parameters. The results showed that the ATELC-Dynamic possessed hist...

During the past decade, the number of studies describing nanostructured lipid carriers (NLCs)-based formulations has been dramatically increased. The raise in NLC exploitation is essentially due to defeated barriers within the technological process of lipid-based nanoparticles' formulation and increased knowledge of the underlying mechanisms of transport of NLCs via different routes of administ...

Prestin is the motor protein of cochlear outer hair cells. It belongs to a distinct anion transporter family called solute carrier protein 26A, or SLC26A. Members of this family serve two fundamentally distinct functions. Although most members transport different anion substrates across a variety of epithelia, prestin (SLC26A5) is unique, functioning as a voltage-dependent motor protein. Recent...

The present study concerns the in vitro and in vivo evaluation of benzocaine (BENZO) and lidocaine (LIDO) topical delivery from nanostructured lipid carriers (NLCs). Morphology and dimensional distribution of NLCs have been, respectively, characterized by differential scanning calorimetry (DSC) and photon correlation spectroscopy. The release pattern of BENZO and LIDO from NLCs was evaluated in...

Outer hair cell (OHC) or prestin-based electromotility is an active cochlear amplifier in the mammalian inner ear that can increase hearing sensitivity and frequency selectivity. In situ, Deiters supporting cells are well-coupled by gap junctions and constrain OHCs standing on the basilar membrane. Here, we report that both electrical and mechanical stimulations in Deiters cells (DCs) can modul...

Application of drug substances to the skin for systemic absorption or action in a particular layer of the skin is a rather old approach. However, over the last years it has received much more attention, as a consequence of the development of new membrane-moderated and matrix reservoir devices. As new reservoir systems, solid lipid nanoparticles (SLN) and nanostructured lipid carriers (NLC) have...

The discovery potential and diagnostic abilities of proposed future colliders for new heavy neutral (Z ) and charged (W ) gauge bosons are summarized. Typical bounds achievable on MZ′,W ′ at the TEVATRON, DITEVATRON, LHC, 500 GeV NLC, and 1 TeV NLC are ∼1 TeV, ∼2 TeV, ∼4 TeV, 1–3 TeV, and 2–6 TeV, respectively. For MZ′ ∼1 TeV the LHC will have the capability to determine the magnitude of normal...

We examine the optimization of NLC parameters at 500, 1000, and 1500 GeV c.m. energy for speci c classes of physics processes, in particular, top and stop pair production, and W-W scattering processes. Our focus is on optimizing the luminosity spectrum, while maintaining or improving machine operability. Presented at Worldwide Study on Physics and Experiments with Future Linear e+eColliders, Ap...