نتایج جستجو برای: neurotoxicity syndromes
تعداد نتایج: 85645 فیلتر نتایج به سال:
Akira Nakajima,1* Kiyofumi Yamada,1,2* Taku Nagai,1 Takehisa Uchiyama,1 Yoshiaki Miyamoto,1 Takayoshi Mamiya,1 Jue He,1 Atsumi Nitta,1 Makoto Mizuno,1 Manh Hung Tran,1 Aika Seto,1 Masako Yoshimura,1 Kiyoyuki Kitaichi,3 Takaaki Hasegawa,3 Kuniaki Saito,4 Yasuhiro Yamada,4 Mitsuru Seishima,4 Kenji Sekikawa,5 Hyoung-Chun Kim,6 and Toshitaka Nabeshima1 1Department of Neuropsychopharmacology and Hos...
Calcineurin has been implicated as part of a critical signaling pathway for learning and memory, and recent data suggest that calcineurin activation mediates some of the neurotoxicity of the Alzheimer related neurotoxin Aβ. Immunosuppression via calcineurin inhibition with the compound FK506 is an important treatment for organ transplant patients. Here we use Golgi impregnation techniques, alon...
Communicating pesticide neurotoxicity research findings and risks to decision-makers and the public.
The extensive research findings on neurotoxic risks of pesticides tend to remain in academic publications rather than being comprehensibly communicated to decision-makers and the public. Protecting health and promoting risk reduction, particularly in developing countries, requires access to current findings in a format that can inform policy, regulations, behaviour change and risk reduction. Su...
The responsiveness to noxious thermal, mechanical, and chemical stimuli was examined in adult rats that had been treated neonatally with capsaicin. A range of capsaicin doses was employed to determine whether the neurotoxicity of capsaicin to primary afferent fibers would be manifested behaviorally in a selective effect on nociceptive thresholds to specific stimuli. Animals were given 5 to 100 ...
The Consensus Workshop on Formaldehyde consisted of bringing together scientists from academia, government, industry and public interest groups to address some important toxicological questions concerning the health effects of formaldehyde. The participants in the workshop, the Executive Panel which coordinated the meeting, and the questions posed, all were chosen through a broadly based nomina...
Objectives. This study aimed to clarify the relationship between community water fluoridation (CWF) and IQ. Methods. We conducted a prospective study of a general population sample of those born in Dunedin, New Zealand, between April 1, 1972, and March 30, 1973 (95.4% retention of cohort after 38 years of prospective follow-up). Residence in a CWF area, use of fluoride dentifrice and intake of ...
Bioactivity-guided fractionation of the methanolic extract of the rhizomes of Imperata cylindrica afforded a new compound, 5-hydroxy-2-(2-phenylethyl)chromone (1), together with three known compounds, 5-hydroxy-2-[2-(2-hydroxyphenyl)ethyl]chromone (2), flidersiachromone (3), and 5-hydroxy-2-styrylchromone (4). Among these four compounds, 1 and 2 showed significant neuroprotective activity again...
The present study aimed to shed more light on the effects of gestational (in utero) exposure to cadmium (Cd) on crucial brain enzyme activities of Wistar rat offspring, as well as to assess the potential protective/restorative role that a Cd-free lactation might have on these effects. In contrast to earlier findings of ours regarding the pattern of effects that adult-onset exposure to Cd has on...
Two persons are described who demonstrated prolonged neuropsychiatric syndromes after the ingestion of large doses of (+-)-3,4-methylenedioxymethamphetamine (MDMA), a recreationally used amphetamine analog. These cases suggest that MDMA, known to be neurotoxic to serotonin neurons in several experimental animals, may also produce untoward effects in humans. In addition, they provide evidence th...
The Functional Observational Battery (FOB) is a neurotoxicity screening assay composed of 25-30 descriptive, scalar, binary, and continuous endpoints. These outcomes have been grouped into six biologically logical domains as a means to interpret the neuroactive properties of tested chemicals (V. C. Moser, 1992, J. Am. Coll. Toxicol. 10(6), 661-669). However, no data-based exploration of these f...
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