نتایج جستجو برای: neurobehavior
تعداد نتایج: 252 فیلتر نتایج به سال:
To demonstrate induction of delayed central nervous toxicity by disturbing neuronal activities in the devetoping brain, we administered a single intraperitoneal dose of domoic acid CDA; 1 mgfkg), a potent glutamate receptor agonist, to pregnant female mice at the gestational day of 1 1 ,5, 14.5 or 17.5, The dams had recovered from acute symptoms within 24 hr, followed by normal delivery, feedin...
BACKGROUND AND PURPOSE To determine the optimal dose of 2-iminobiotin (2-IB) for the treatment of moderate to severe asphyxia in a neonatal piglet model of hypoxia-ischemia. METHODS Newborn piglets were subjected to a 30-minute hypoxia-ischemia insult and randomly treated with vehicle or 2-IB (0.1 mg/kg, 0.2 mg/kg, or 1.0 mg/kg). aEEG background and seizure activity were scored after hypoxia-...
Mashimo, Tomoji, Birger Voigt, Takashi Kuramoto, and Tadao Serikawa. Rat Phenome Project: The untapped potential of existing rat strains. J Appl Physiol 98: 371–379, 2005; doi:10.1152/ japplphysiol.01006.2004.—The National Bio Resource Project for the Rat in Japan collects, preserves, and distributes rat strains. More than 250 inbred strains have been deposited thus far into the National Bio Re...
This study set out to assess the neurobehavioral effects of subchronic, oral bromocriptine methanesulfonate using the open field and the Y-maze in healthy male mice. Sixty adult Swiss albino mice were assigned into three groups. Controls received normal saline, while test groups received bromocriptine methanesulfonate at 2.5 and 5 mg/kg/day, respectively, for a period of 21 days. Neurobehaviora...
Prenatal cocaine exposure causes profound changes in neurobehavior as well as synaptic function and structure with compromised glutamatergic transmission. Since synaptic health and glutamatergic activity are tightly regulated by brain-derived neurotrophic factor (BDNF) signaling through its cognate tyrosine receptor kinase B (TrkB), we hypothesized that prenatal cocaine exposure alters BDNF-Trk...
OBJECTIVE To investigate the effects of early experience on brain function and structure. METHODS A randomized clinical trial tested the neurodevelopmental effectiveness of the Newborn Individualized Developmental Care and Assessment Program (NIDCAP). Thirty preterm infants, 28 to 33 weeks' gestational age (GA) at birth and free of known developmental risk factors, participated in the trial. ...
BACKGROUND The mechanisms underlying the protective effects of hyperbaric oxygen (HBO) therapy on traumatic brain injury (TBI) are unclear. TBI initiates a neuroinflammatory cascade characterized by activation of microglia and increased production of proinflammatory cytokines. In this study, we attempted to ascertain whether the occurrence of neuroinflammation exhibited during TBI can be reduce...
Maternal zinc deficiency during pregnancy has been related to adverse effects on progeny, and there are data showing that mild to moderate zinc deficiency (as assessed by available indicators) is quite common in the developing world. Observational data relating zinc deficiency to adverse fetal outcome have produced conflicting results, mainly because of the lack of a valid indicator of zinc def...
Increasing use of engineered nanomaterials (ENM) in consumer products and commercial applications has helped drive a rise in research related to the environmental health and safety (EHS) of these materials. Within the cacophony of information on ENM EHS to date are data indicating that these materials may be neurotoxic in adult animals. Evidence of elevated inflammatory responses, increased oxi...
Objective: This study aimed to compare the diagnostic value of 4 questionnaires for the diagnosis of neurocognitive disorders (NCDs) in the elderly. Methodology: In this project, people older than 60 years who lived in Tehran were investigated. A total of 99 literate persons were enrolled in the study, and 4 questionnaires of functional assessment staging tool (FAST), abbreviated mental test s...
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