Behçet's disease (BD) is a systemic inflammatory disease having a chronic and prolonged course with 4 major symptoms: oral and genital ulcerations, eye disease and cutaneous manifestations, as well as other multisystem involvements. Arterial involvement is a comparatively rare complication in BD and coronary lesions are extremely rare. We report here two cases of BD presenting as myocardial inf...

Scleritis is a severe painful inflammatory process centred in the sclera. A scleritis may be a harbinger of many systemic diseases so that it is important to exclude multisystem disease. We describe a case of unilateral tubercular anterior nodular non-necrotizing scleritis. Anterior nodular non-necrotizing scleritis is relatively an uncommon manifestation of tuberculosis. It may be difficult to...

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by increased inflammation, and results from gene-environment interactions. Proteinase-activated receptor-1 mediates the interplay between coagulation and inflammation. The rs2227744G > A promoter single nucleotide polymorphism has been linked to inflammation, cardiovascular disease and chronic obstructive pulm...

Survival in cystic fibrosis (CF) has improved vastly. While proactive treatment of lung disease and malabsorption remain the cornerstones of CF care; recognition and interventions in other aspects of this multisystem disorder can allow these patients to achieve a good quality of life and improve all round general health. Bone disease is probably one of the less well recognized complications of ...

Polycystic kidney disease is an inherited multisystem disorder. It causes progressive loss of kidney function, flank pain, urinary tract infection, arterial hypertension and vascular abnormalities. Until the present time the treatment of polycystic kidney disease has been symptomatic. New approaches based on cell culture of cyst wall epithelia and on the discovery of polycystins 1 and 2 have le...

Introduction Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease characterized by a variable clinical picture and serological abnormalities. Children and adolescents generally have a more severe disease presentation; develop disease damage more quickly than adults with SLE. Diffuse alveolar hemorrhage (DAH) is a rare life-threatening complication in SLE. In this report a case...

Sarcoidosis is a multisystem granulomatous disease of unknown aetiology characterized by infiltration of non caseating granulomas in multiple organ systems. Sarcoidosis can have a plethora of cardiac manifestations which can mimic many other cardiovascular conditions ranging from asymptomatic electrocardiographic manifestations to life threatening arrhythmias resulting in sudden cardiac death. ...

Introducion. COVID-19 in children is a relatively mild disease. Though more serious condition characterized by systemic inflamma- tion does occur Kawasaki disease-like form named multisystem inflammatory syndrome (MIS-C). MIS-C less common pathology. Case Report. A clinical case of (MIS-C) temporally associated with SARS-CoV-2 in- fection previously healthy preschool-age girl presented. The dis...