Overcoming preexisting immunity to vaccinia virus in the adult population is a key requirement for development of otherwise potent recombinant vaccinia vaccines. Based on our observation that s.c. immunization with vaccinia induces cellular and antibody immunity to vaccinia only in systemic lymphoid tissue and not in mucosal sites, we hypothesized that the mucosal immune system remains naive to...

Mucosal surfaces account for the vast majority of HIV transmission. In adults, HIV transmission occurs mainly by vaginal and rectal routes but rarely via oral route. By contrast, pediatric HIV infections could be as the result of oral route by breastfeeding. As such mucosal surfaces play a crucial role in HIV acquisition, and spread of the virus depends on its ability to cross a mucosal barrier...

IBDs (inflammatory bowel diseases) are a group of diseases affecting the gastrointestinal tract. The diseases are multifactorial and cover genetic aspects: susceptibility genes, innate and adaptive responses to inflammation, and structure and efficacy of the mucosal protective barrier. Animal models of IBD have been developed to gain further knowledge of the disease mechanisms. These topics for...

Annotation. The study aimed to analyze references in the scientific literature on hard dental tissue damage and periodontal oral mucosal diseases patients with concomitant gastrointestinal tract pathology. We used bibliosemantic method identify status of outlined issues analysis research data. Based data from national international published topic, prevalence, severity structurality changes org...

BACKGROUND Worldwide, female sex workers (FSW) represent a vulnerable population for oral diseases due to many risk factors including HIV infection and drug abuse. In sub-Saharan Africa, little is known about the burden of oral diseases and their determinants in vulnerable populations. The aim of the study was to estimate the prevalence and associated factors of oral diseases among FSW. METHO...

Background Gallbladder carcinoma (GBC) sometimes presents with nonspecific signs, without forming a mass, mimicking benign gallbladder (GB) diseases. On the contrary, benign GB diseases may mimic GBC. Material and Methods We retrospectively reviewed 107 cases over a period of 3 years (May 2012-April 2015), which included 41 review cases and 66 departmental cases. Carcinoembryonic antigen (CEA...

BACKGROUND The human gut is an ecosystem consisting of a great number of commensal bacteria living in symbiosis with the host. Several data confirm that gut microbiota is engaged in a dynamic interaction with the intestinal innate and adaptive immune system, affecting different aspects of its development and function. AIM To review the immunological functions of gut microbiota and improve kno...

OBJECTIVE To study the severity of symptoms and estimate the prevalence of oral mucosal lesions in a non-referral adult Swedish population, as registered by general dental practitioners. This study also aims to evaluate the possibility of dental practitioners collecting large quantities of reliable and accurate clinical data on oral mucosal lesions. STUDY DESIGN Data from 6,448 adult Swedish ...

Relevance . Viral diarrhea — mucosal disease of cattle is widespread throughout the world, including Russia. The virus causes immunosuppression, pathology gastrointestinal and respiratory tract. But greatest economic damage due to culling heifers lactating cows as a result pathologies reproductive system. included in "List contagious other animal diseases", approved by order No. 62 Ministry Agr...

Expanding bilateral sphenoid sinus plasty is an essential technique for the treatment of diseases, such as refractory sinusitis, cyst, fungal carcinoma and chordoma. The present study evaluated potential application expanding in diseases. A retrospective medical record review 42 patients treated with from December 2012 to 2018 was performed a tertiary‑care university hospital. follow‑up surgica...