the emergence of plasmodium vivax in dashte moghan in northwestern iran has become a major concern for iranian's health officials. knowledge of genetic make up of the p. vivax populations in this area would give us an insight into the origin of the prevalent infections and the possible routes they are introduced. this paper reports the analysis of a variable region between the two interspecies ...

recurrent aphthous stomatitis (ras) is known as the most common chronic disease of the oral cavity, which affects a range of 5-25% of the population. ras appears to be associated with some human leukocyte antigen (hla) class ii alleles and haplotypes. this study attempts to survey the distribution of hla-drb and -dqb alleles among iranian ras patients and healthy controls. in order to evaluate ...

background: we aimed to value the usefulness of free to total prostate-specific antigen and prostate-specific antigen (psa) density for prostate cancer in the patients with psa levels of 4.0 ng/ml or less. methods: a total of 343 subjects with psa levels of 4.0 ng/ml or less were biopsied. all patients were divided into four groups according to the psa levels: 0 to 1.0 ng/ml, 1.1 to 2.0 ng/ml, ...

objective(s) the aim of this study was to evaluate the expressions of two angiogenic immune-markers (cd-31 and vegf), and one proliferative immune-marker (ki-67) in oral pyogenic granulomas (pg), hemangiomas (hem) and inflammatory gingivitis (ig). materials and methods sixty cases of pg, hem and ig (twenty cases each) were examined. immunohistochemical (ihc) staining was performed based on rout...

background: dense granule antigens (gra antigens) of toxoplasma gondii induce strong antibody response in humans and are considered as useful diagnostic antigens. previous studies reported expression of amino terminal gra8 protein in fusion with large tags such as glutathione-s-transferase. the present study aimed to produce soluble full length immunogenic gra8 in bacteria. methods: gra8 comple...

introduction: although extensive research has been conducted on lung cancer markers, a singular clinically applicable marker has not been found yet. the objective of this study was to evaluate the sensitivity and the specificity of carcinoembryonic antigen (cea) mrna and lung-specific x protein (lunx) mrna biomarkers in peripheral blood to detect lung cancer individually and simultaneously. met...

conclusions in comparison with the rate of hbcab positivity reported in other iranian studies, the rate was higher in the present study. there were a few variations, genotypes, and subtypes among the infected injecting drug users. further investigations are needed to unravel the molecular characterization of obi. results sixty-four (28%) participants were hbcab positive, 59 cases were hbcab pos...

host genetic factors play a central role in determining the clinical phenotype of human diseases. association between two polymorphic loci in human genome, human leukocyte antigen (hla) and killer cell immunoglobulin-like receptors (kirs), and genetically complex infectious disease, particularly those of viral etiology, have been historically elusive. hence, defining the influence of genetic di...

background periapical lesions are induced in response to injuries to periapical tissues, which are generally the result of infections within the root canal. mast cells actively participate to the inflammatory infiltration of periapical granulomas and cysts. objectives the aim of this study was to detect and compare the presence of mast cells in inflammatory periapical lesions, including cysts a...