BACKGROUND The aim of this study was to investigate the thickness of the retinal nerve fiber layer (RNFL), the ganglion cell layer (GCL), and choroid thickness (CT) in patients who have migraines, with and without aura, using spectral optical coherence tomography (OCT). METHODS Forty-five patients who had migraines without aura (Group 1), 45 patients who had migraines with aura (Group 2), and...

BACKGROUND AND PURPOSE The aura phase of migraine is associated with focal blood flow changes, but it has been largely unknown whether these changes are correlated to changes in the cerebral metabolism. METHODS Eight patients required carotid angiography for evaluation of transient neurological attacks. Cerebral blood flow (CBF) results, angiography, and clinical observations subsequently sug...

Objective: To determine whether smaller atrial shunts (large persistent foramen ovale (PFO) and small atrial septal defect (ASD)) are inherited and whether this has a role in the inheritance of migraine with aura. Methods: Contrast echocardiography was used to detect atrial shunts in 71 relatives of 20 probands with a significantly sized atrial shunt (large PFO or ASD). Four families with three...

We investigated whether three relevant polymorphisms (C-1562T, microsatellite -90(CA)(14-24), and Q279R) in the MMP-9 gene, or MMP-9 haplotypes, are associated with migraine and affect MMP-9 and tissue inhibitor of MMPs (TIMP)-1 levels in patients with migraine. We studied 102 healthy women (controls) and 187 women with migraine (141 without aura - MWA, and 46 with aura - MA). Patients with MWA...

BACKGROUND Migraine is a complex disease whose physiopathological mechanisms are still not completely revealed. FINDINGS We describe an unusual case, not yet described in literature, of a patient who reported migraine remission, but still presented aura attacks, since starting a therapy with Warfarin. CONCLUSIONS This case report brings out new questions on the role of the coagulation, espe...

CONTEXT Clinical series have suggested an increased prevalence of cerebral infarction and white matter lesions (WMLs) in migraine patients. It is not known whether these lesions are prevalent in the general migraine population. OBJECTIVES To compare the prevalence of brain infarcts and WMLs in migraine cases and controls from the general population and to identify migraine characteristics ass...

Background: Visual evoked potential (VEP) is regarded as a useful, reliable and non-invasive technique for the diagnosis of lesions in the optic pathway.  This technique was used to investigate visual function in migraine.   Materials and Methods: 53 migraine patients (27 migraine cases with aura and 26 common migraine cases) and 55 controls were prospectively enrolled in this study.  Visual ev...

background: migraine is a chronic disease that affects nearly 6% of men and 18% of women worldwide. there are various drugs, which can successfully decrease migraine symptoms and frequency of migraine attacks, but these drugs usually are expensive. hence, this study aimed to assess the effects of pyridoxine  supplementation on severity, frequency and duration of migraine attacks as well as head...

Migraine is a neurological disorder characterized by an increased individual susceptibility to respond to certain triggers by a propagating wave of neuronal depolarization that culminates in typical migraine headaches. Patients with a patent foramen ovale or any kind of right-to-left shunt are more likely to have migraine; and patients with migraine with aura are more likely to have a patent fo...

This study analysed how migraine patients assume to improve their daily life if wearable sensors provide them pre-warnings of approaching or impending attacks. The the use new technology in identifying pre-symptoms using Technology Acceptance Model (TAM) focusing on assumed usefulness a device. added understanding getting accept smart support own treatments. results were drawn from sample altog...