EDITOR, I read the recent publication by Savaj and colleagues in the Iranian Journal of Kidney Disease with great interest.1 Savaj and colleagues reached to the conclusion that “MDRD [the modification of diet in renal disease] equation could provide a closer estimate of GFR [glomerular filtration rate] to the cystatin C-based equations than other creatinine-based GFR calculations in kidney tran...

OBJECTIVE Chronic kidney disease (CKD) is considered to be one of the most common risk factors for cardiovascular diseases. Glomerular filtration rate (GFR) is the best method of testing level of kidney function and determining stage of kidney disease. The aim of this study was to examine the impact of renal function on severity of coronary heart disease (CHD). METHODS The present study inclu...

Aim. To compare two creatinine-based estimated glomerular filtration rate (eGFR) equations, the chronic kidney disease epidemiology collaboration (CKD-EPI) and the modification of diet in renal disease (MDRD), for predicting the risk of CKD progression in type 2 diabetic patients with nephropathy. Methods. A total of 707 type 2 diabetic patients with 24 hr urinary albumin excretion of more than...

Sir, The interesting paper by Taylor et al. [1] lends support to the idea that the variables used in the different formulas to estimate GFR (glomerular filtration rate) are surrogate markers of lean body mass. The following letter by Rigalleau et al. [2] did not fully confirm the findings, at least in diabetic patients. We are rather puzzled by a part of the analysis conducted in the Taylor’s p...

A decline in renal function suggests progression of chronic kidney disease. This can be determined by measured GFR (e.g., iothalamate clearance), serum creatinine (SCr)-based GFR estimates, or creatinine clearance. A cohort of 234 patients with autosomal dominant polycystic kidney disease and baseline creatinine clearance>70 ml/min were followed annually for four visits. Iothalamate clearance, ...

BACKGROUND To study the renal function (FR) of the hypertensive patients by means of estimating equations and serum creatinine (Crp). To calculate the percentage of patients with chronic kidney disease (ERC) that present normal values of Crp. To analyze which factors collaborate in the deterioration of the FR. METHODS Descriptive cross-sectional study of patients with HTA. Crp and arterial te...

BACKGROUND Few studies have addressed the link between minor renal dysfunction and mortality in the elderly. AIM To compare three equations for estimated GFR (eGFR) in assessing renal dysfunction and predicting mortality in an elderly population. DESIGN Longitudinal observational study. METHODS We studied 441 people from the Jerusalem Seventy Year Olds Longitudinal Study who had measureme...

OBJECTIVE The aim of this study was to compare cystatin C versus creatinine as a marker for acute kidney injury in patients submitted to cardiac surgery with cardiopulmonary bypass. METHODS Fifty consecutive patients submitted to coronary artery bypass grafting were studied. Renal function was evaluated by serum cystatin C and creatinine. Blood samples were obtained from each patient at three...

G FR is the accepted metric for evaluating renal function but measuring it directly (mGFR) can be cumbersome, time-consuming, and costly. The constant infusion method using inulin as the filtration marker, introduced in 1934 by Richards and Smith (1), has undergone many revisions that have now made mGFR easier to perform, although not widely available (2,3). A simple, reliable, unbiased, precis...

Background—Limited data suggest that HMG-CoA reductase inhibitors (statins) reduce rates of kidney function loss. We performed this analysis to determine whether pravastatin reduced the rate of kidney function loss over 5 years in people with or at high risk for coronary disease. Methods and Results—This was a post hoc subgroup analysis of data from 3 randomized double-blind controlled trials c...