The aim of this study was to investigate the function of the Hippo pathway member Yes-associated protein (Yap, gene name Yap1) in skeletal muscle fibres in vivo. Specifically we bred an inducible, skeletal muscle fibre-specific knock-in mouse model (MCK-tTA-hYAP1 S127A) to test whether the over expression of constitutively active Yap (hYAP1 S127A) is sufficient to drive muscle hypertrophy or st...

OBJECTIVE Lipoprotein lipase (LPL) is a principal enzyme in lipoprotein metabolism, tissue lipid utilization, and energy metabolism. LPL is synthesized by parenchymal cells in adipose, heart, and muscle tissues followed by secretion to extracellular sites, where lipolyic function is exerted. The catalytic activity of LPL is attained during posttranslational maturation, which involves glycosylat...

SYMPOSIUM PROCEEDINGS 1964 Blaxter, K. L. & Wilson, R. S. (1963). Anim. Prod. 5, 27. Campling, R. C. (1964). Proc. Nutr. SOC. 23, 80. Cooper, J. P., Tilley, J. M. A., Raymond, W. F. & Terry, R. A. (1962). Nature, Lond., 195, 1276. Dent, J. W. (1963). Proc. 1962 Crop Conference, National Institute of Agricultural Botany, Cambridge. Dodsworth, T. L. & Campbell, W. H. McK. (1953). J . agric. Sci. ...

Studies in invertebrates have indicated a functional requirement for presenilin (PS) genes in the Notch pathway [1-5]. One model of Notch signal transduction suggests that proteolysis releases an activated Notch fragment that migrates to the nucleus and regulates gene transcription in concert with CBF1/Su(H)/lag1 (CSL) proteins [6-9]. Recent studies suggest that PS genes control the proteolysis...

A large body of research has contributed to our understanding of the pathophysiology of diabetic nephropathy. Yet, many questions remain regarding the progression of a disease that accounts for nearly half the patients entering dialysis yearly. Several murine models of diabetic nephropathy secondary to Type 2 diabetes mellitus (T2DM) do exist, and some are more representative than others, but a...

The well characterized human breast cancer cell line, MCF-7, has been shown to possess membrane receptors for various opioid ligands, and these compounds have been shown to modulate the growth of the cells in culture. Using specific radioligands for the receptor types, we were able to demonstrate that the MCK-7 cells possess multiple opioid receptor types. Relatively high-affinity-binding sites...

Polymorphisms of genes encoding key factors for the control and activation of inflammatory response and coagulation cascade regulation may play a role in genetic susceptibility to acute myocardial infarction (AMI). This study sought to analyze the effect of TNF -308G/A and pro-thrombin (FII) 20210G/A polymorphisms on the laboratory parameters of young patients affected by AMI. Results indicated...

Myogenic helix-loop-helix (HLH) proteins, such as myogenin and MyoD, can activate muscle-specific transcription when introduced into a variety of nonmuscle cell types. Whereas cells of mesodermal origin are especially permissive to the actions of these myogenic regulators, many other cell types are refractory to myogenic conversion by them. Here we describe a novel homeodomain protein, MHox, th...

Indoor positioning and tracking services are garnering more attention. Recently, several state-of-the-art localization techniques have been proposed that use radio maps or the sensors readily available on smartphones. This paper presents a localization system called Construction of indoor floor plan And LocaLization (CALL), which is based on a floor plan, access points (APs), and smartphone sen...

4 Tchirkow GT, Lavery IC, Fazio VW. Crohn's disease in the elderly. Dis Colon Rectum 1983;26: 177-81. 5 Goligher JC. Crohn's disease (granulomatous enteritis). In: Goligher JC, de Dombal FT, Watts J McK. Surgery ofthe anus, rectum and colon. 4th ed. London: Bailliere, Tindall, 1980:827-57. 6 Kyle J. An epidemiological study of Crohn's disease in north east Scotland. Gastroenterology 1971 ;61:82...