background & aim: preeclampsi which is a common and important disorder in pregnancy is one of the three leading causes of maternal mortality. it is worthy to find out an appropriate screening test for it. this study aimed to assess serum hematocrit level as a screening test for preeclampsia. methods & materials: using a randomized stratification, 660 women who were in the 24-28 weeks of gestati...

Discovery of cell free fetal DNA in 1997 has deeply changed the outlook of prenatal diagnosis approaches as most of the clinically established screening tests are not sensitive/specific enough while the current practical diagnostic tests are also invasive in their nature. The most common prenatal screening test is routinely practiced for the diagnosis of Down syndrome (DS) which includes a 10% ...

OBJECTIVE To examine the potential value of maternal serum level of α-fetoprotein (AFP) in the first trimester of pregnancy in the prediction of spontaneous early preterm delivery. METHODS Maternal serum concentration of AFP at 11-13 weeks' gestation was measured in a case-control study of singleton pregnancies delivering phenotypically normal neonates, including 33 cases with spontaneous del...

OBJECTIVE To investigate the potential value of repeat measurements of maternal serum concentration of soluble fms-like tyrosine kinase-1 (sFlt-1) at 22 and 32 weeks' gestation in the prediction of pre-eclampsia (PE) in women delivering after 32 weeks. METHODS The data were derived from prospective screening for adverse obstetric outcomes in women attending their routine hospital visit at 19-...

OBJECTIVE The objective of this study were to (1) quantify the concentrations of inhibin A, activin A, and follistatin in maternal serum and umbilical vein (inhibin A, activin A) in IUGR due to placental dysfunction pregnancies and control group, (2) determine the concentration differences of these factors in maternal and umbilical vein serum in control and subject group, and (3) examine the re...

background: recto-vaginal colonization of group b streptococcus (gbs) has been known as an important issue in mother and newborn’s health, which is getting frequent in developing countries. screening test have been introduced and utilized in many countries and is recommended by many researchers. however, due to lack of information in prevalence of gbs, especially in iran, there are doubts and c...

OBJECTIVE To examine the potential role of maternal serum level of adiponectin in the first trimester of pregnancy in the prediction of neonatal macrosomia. METHODS Maternal serum adiponectin concentration was measured in a case-control study of singleton pregnancies at 11 to 13 weeks' gestation, which included 50 cases that subsequently delivered macrosomic neonates with birth weight above t...