Phytoestrogens Hepatocellular carcinoma Chemoprevention Hepatocellular carcinoma (HCC) is the commonest primary malignant cancer of the liver and the third leading cause of cancer mortality worldwide. Statistically liver cancer is the fifth most common cancer in men and the 7th most common cancer in women. The major common risk factors for hepatocellular are hepatitis B (HBV) and hepatitis C vi...

Lignans are mainly dimers of 4-hydroxycinnamic acids (HCAs) and reduced analogs thereof which are produced in Nature through phenol oxidative coupling (POC) as the primary C-C or C-O bond-forming reaction under the action of the enzymes peroxidases and laccases. They present a large structural variety and particularly interesting biological activities, therefore, significant efforts has been de...

Lignans are a large class of natural products that have been isolated from many plants. They reveal diverse biological activities, especially antiviral and antitumor properties. From Piper cubeba, lignans of several classes can be isolated from the roots, rhizomes, stems, leaves, seeds, and fruits. Among its various chemical constituents, (-)-cubebin and (-)-hinokinin are found in significant q...

The present article describes the chemical characteristics such as pH of aqueous extract, fluorescence, aqueous and alcoholic extractives, lignans and TLC profile of aqueous extract of Bhuiavli (Phyllanthus niruri).

Phytochemical studies of whole plant of Phyllanthus debilis Klein.ex.willd (Euphorbiaceae) reveals the presence of phytosterols, lignans, glycosides and absence of saponin, triterpenoids, tannins and alkaloids have been reported in this plant for the first time.

Lignans and proanthocyanidins are plant polyphenols that have shown protective properties against colorectal neoplasms in some human studies. Using logistic regression, we estimated odds ratios (ORs) and 95% confidence intervals (CIs) to prospectively evaluate the association between lignan and proanthocyanidin intake, estimated from databases linked to a food frequency questionnaire, and adeno...

Giardiasis, a diarrheal disease, is highly prevalent in developing countries. Several drugs are available for the treatment of this parasitosis; unfortunately, all of them have variable efficacies and adverse effects. Bursera fagaroides has been known for its anti-inflammatory and antidiarrheal properties in Mexican traditional medicine. We investigated the in vitro anti-giardial activities of ...

Chemical investigation of Vitex negundo seeds afforded four new lignans, including a phenylindene-type lignan, vitexdoin F (1), and three phenylnaphthalene-type lignans, vitexdoins G, H and I (2-4). Their structures were elucidated by detailed spectroscopic analyses on the basis of NMR, IR, and MS data. All compounds were evaluated for their anti-inflammatory and anti-osteoporotic activities, e...