Myelodysplastic syndromes (MDS) are a heterogeneous group of neoplastic diseases the hematopoietic cells manifested by ineffective hematopoiesis and tendency to transform into acute myeloid leukemia. MDS should be considered in differential diagnosis cytopenia, especially elderly. This article presents recommendations experts Polish Adult Leukemia Group (PALG) for myelodysplastic syndromes. We ...


 Acute Lymphocytic leukemia (ALL) is the most common childhood malignancy, CNS involvement occurs in 3-5% of patients. We present a case 14-year-old boy who presented to us with nighttime fever, headache, and right-sided focal fits. Reports showed decreased platelets, increased WBC predominant eosinophils imaging subgaleal, epidural subdural collection. Bone marrow biopsy CSF analysis wer...

abstract background: varicella is a highly contagious and dangerous disease especially in immunocompromised patients. children with cancer are at increased risk of severe illness and may fatal cases occur. vaccination from vzv ( varicella zoster vaccine) infection can be safe, immunogenic, and effective in children with leukemia who meet the criteria and are at the risk of serious disease or de...

Background: The induction chemotherapy regimen for acute myeloid leukemia has evolved as once induction is completed patients progress through the consolidation phase and achieve remission in 76% of cases. For patients with relapsed or refractory disease, alternative chemotherapy agents are available. Monoclonal antibody therapy with biological agents, such as the immunotoxin gemtuzumab ozog...

Background Acute lymphoblastic leukemia (ALL) is a bone marrow and blood neoplasm involving precursor cells, or lymphoblasts, dedicated to B/T-cell lineages. ALL usually presents with bicytopenia/pancytopenia thrombocytopenia the most important key parameter. Thrombocytosis has not been well-described feature of ALL; hence, this study was planned investigate incidence thrombocytosis at initial ...

Background: Efficacy of rasburicase in pediatric patients with leukemia and lymphoma is proved. This study aims toweigh efficacy and safety of rasburicase versus more conventional therapy, allopurinol, and to compare their safetyand properties in tumor lysis syndrome (TLS) of leukemia and lymphoma patients.Materials and Methods: The study was done with a retrospective cohort design. Patients we...

Introduction: GTPase regulator associated with focal adhesion kinase (GRAF) is a recently identified GTPase activating protein that has the tumor suppressor properties. However, the expression level of GRAF in leukemia had received less attention. The main purpose of this research was the evaluating of the expression level of GRAF in patients with acute myeloid leukemia (AML). Materials and met...

Childhood Hepatitis B virus (HBV) infection causes both medical and public health challenges. Infants who acquire HBV parentally have up to 90% risk of developing chronic HBV infection. It is now estimated that approximately 10% of worldwide cancers are attributable to viral infection, with the vast majority (>85 %) occurring in the developing world. In this distribution, elevated rate and prev...

Acute lymphoblastic leukemia (ALL) constitute a family of genetically heterogeneous lymphoid neoplasms derived from B- and T-lymphoid progenitors. ALL affects both children and adults. Diagnosis is based on morphologic, immunophenotypic, and genetic features that allow differentiation from normal progenitors and other hematopoietic and nonhematopoietic neoplasms. The aim of this study was to in...