Background: Five proton pump inhibitors are now available for use in North America. Claims of differences in the clinical efficacy of different strengths and/or agents have been made. Aim: To identify any consistent evidence of differences in outcomes between agents or doses within this class of drugs. Methods: A search of the medical literature was performed in two electronic databases, and ra...

The effects of pantoprazole on xenobiotic metabolizing enzymes in rat liver microsomes were examined. Groups of female Sprague-Dawley rats were orally administered pantoprazole and other proton pump inhibitors, omeprazole and lansoprazole, at 5, 50, or 300 mg/kg/day for 7 days, followed by assays to detect changes in the levels of liver microsomal protein, cytochrome P450, cytochrome b5, NADPH ...

After oral and intravenous administration of [14C]clarithromycin to rats, c. 60-70% of the radioactivity in the gastric tissue was found to be distributed in the mucosal layer. Co-administration of lansoprazole and amoxicillin had no apparent effect on this distribution pattern of [14C]clarithromycin. The amount of unchanged [14C]clarithromycin in gastric contents increased with co-administrati...

cow’s  milk  anaphylaxis is  the  most  common  food-induced  anaphylaxis in  iranian children. the clinical and laboratory findings of cow’s milk anaphylaxis are evaluated in this study. all children who had experienced cow’s  milk anaphylaxis and had been referred to immunology, asthma and allergy research center during a 5-year period were considered. after fulfilling a questionnaire, patien...