In regression analysis for deriving scaling laws in the context of fusion studies, usually standard regression methods have been applied, of which ordinary least squares (OLS) is the most popular. However, concerns have been raised with respect to several assumptions underlying OLS in its application to fusion data. More sophisticated statistical techniques are available, but they are not widel...

In HL-60 cells, retinoic acid (RA) and 9 cis-RA induce granulocytic differentiation, and calcitriol and sodium butyrate induce monocytic differentiation. To study the role of retinoid resistance on the response to these agents, we investigated their effects in HL-60 cells, retinoid-resistant HL-60R cells, and HL-GOR+ cells in which retinoid sensitivity has been restored. In HL-60 cells, catheps...

AIM To investigate whether pharmacogenetic loci or metabolite concentrations explain clinical response or side effects to AZA. METHODS Patients with IBD were given 2 mg/kg of AZA without dose escalation or adjustment. Serial clinical response, thiopurine methyl transferase (TPMT) activity and thioguanine nucleotide (TGN) concentrations were measured over 6 months. All patients were genotyped ...

Experiments designed to characterize both stable and unstable Alfvén eigenmodes are a key part of the Alcator C-Mod physics program. Stable intermediate toroidal mode number (3 ≤ n ≤ 14) Alfvén eigenmodes, which are expected to be the most unstable in ITER, are excited with a set of active MHD antennas and their damping rates are measured as a function of plasma parameters. This is part of an i...

BACKGROUND Language disorder (LD) is a neurodevelopmental disorder, and early diagnosis has an impact on speech therapy practice. The aim of this work is to test the usefulness of the Cognitive and Language scales of the Bayley-III in the early diagnosis of LD. METHOD In a longitudinal study, a clinical sample of 187 children with diagnostic hypothesis of communication disorders at 4.5 years ...

Introduction: Previous studies revealed that oxidative stress is elevated in multiple sclerosis (MS). It can harm to biological macromolecules such as DNA. However, the molecular mechanism in protection of genetic information from DNA damages is not clear in MS disease. In this study the expression level of some important genes of OGG1 and MYH involved in base excision repair pathway and, MTH1 ...

Direct-acting antiviral drugs (DAAs) are currently replacing antiviral therapy for Hepatitis C infection. Treatment related side effects are even worse and the emergence of resistant viruses must be avoided because of the direct-antiviral action. Altogether it remains a challenge to take treatment decisions in a clinical setting with cost restrictions. Genetic host factors are hereby essential ...

MLL amplification was recently recognized as a recurrent aberration in acute myeloid leukemia (AML) and myelodys-plastic syndrome (MDS), associated with adverse prognosis and karyotype complexity. Here we present detailed results of fluorescence in situ hybridization (FISH) and expression analyses of MLL and 5 selected 11q candidate oncogenes (CBL, DDX6, ETS1, FLI1, and PLZF) in 31 patient samp...