Intraocular metastatic tumor is the commonest intraocular malignancy in adults, with uveal tract the commonest site. In nearly 85% of cases the choroid is the afflicted site due to its vascularity. Breast and lung are the common primaries. In breast primaries, this could be the first metastatic disease. This condition should always be kept in mind in patients with visual symptoms. Fundus examin...

F Case 1 is a 20 year old woman, with known amblyopia o the left eye, who developped a massive intraocular hemorrhage leading to refractMy glaucoma, necessitating enucleation. Case 2 concerns a 68 year old woman also presenting a sevex intravitreal hem&age associated with a history of progressive visual loss over the past weeks. Repeated ultrasound examinations in case 1 showed a macular “staph...

Choroidal osteoma is a rare intraocular bony tumor that typically manifests as a yellow-white, well-demarcated mass with geographic pseudopodal margins.1-3 This benign tumor predominantly occurs in the peripapillary or papillomacular region, most often in young women.1,2 Occasionally, choroidal osteoma can simulate an amelanotic choroidal tumor such as melanoma, nevus, or metastasis.1,2 This tu...

Retinoblastoma (Rb) is an intraocular tumor usually diagnosed in children under four years of age (1). The tumor rises when both alleles of the Rb tumor suppressor gene become inactivated in a retinal precursor cell during development (2,3). The first retinoblastoma cell line to be established in culture, Y-79 (4), has been shown to originate from neuroectodermal cells that express both neurona...

Uveal melanoma (UM) is rare, but it the most common primary intraocular malignancy among adults. This review represents molecular, genetic, and immunobiological mechanisms involved in UM carcinogenesis progression, as well data about association of chromosomal changes, genetic mutations, selective proteins, biochemical biomarkers with clinical implications UM. Genetic analysis has potential to ...

purpose : to compare the intraocular pressure (iop) lowering effect and side effects of xalatan with generic latanoprost (xalabiost) in adults with open-angle glaucoma or ocular hypertension methods : this was a two-center prospective randomized, crossover clinical trial. eligible patients with open-angle glaucoma or ocular hypertension were sequentially randomized to two parallel study groups ...

We report a 6-month-old boy who presented with unilateral leukocoria, retinal detachment, and a retrolental mass in a microphthalmic eye based on retinal dysplasia with concurrent optic nerve aplasia. Dysplastic retinal tissue, a rare congenital defect, may create a clinical and radiologic picture of an intraocular mass closely resembling tumor tissue. MR imaging findings with histopathologic c...

PURPOSE Primary intraocular lymphoma (PIOL) is a subtype of central nervous system lymphoma. Although this lymphoma is rare, its incidence has tripled in the past 15 years. Currently, the only available model is a murine metastatic malignant lymphoma that occurs after intraperitoneal inoculation of Rev-2-T-6 lymphoma cells into newborn syngeneic mice. The current study was conducted to develop ...

PURPOSE To study the differential expression of microRNA (miRNA) profiles between intraocular medulloepithelioma (ME) and normal control tissue (CT). MATERIAL AND METHODS Total RNA was extracted from formalin fixed paraffin embedded (FFPE) intraocular ME (n=7) and from age matched ciliary body controls (n=8). The clinical history and phenotype was recorded. MiRNA profiles were determined usin...