BACKGROUND AND PURPOSE The aim of this study was to investigate the regional differences in the in vivo vasodilator responses to vasopressin, which is thought to stimulate the release of nitric oxide from the endothelium, in canine cerebral arteries by angiography. METHODS Angiograms were performed through a catheter inserted directly into the right vertebral artery and were taken periodicall...

introduction: vertebral arteries arise from the root of the neck as the first branches from the superior-posterior aspect of the subclavian arteries. they ascend the neck to enter the cranial cavity and supply blood to the brain. methods: a total of 20 cadavers (in 10 years) were dissected for the study of variations in the origin of the vertebral artery. this study was conducted in isfahan uni...

Moyamoya disease is a stenoocclusive disease involving the intracranial carotid and proximal middle cerebral arteries. There are rarely any additional extracranial stenoses occurring concurrently with moyamoya. The pathophysiology of moyamoya remains obscure, but hematologic disorders, notably sickle-cell anemia, have been associated in some cases. We describe the novel case of polycythemia ver...

BACKGROUND AND PURPOSE MR angiography is primarily and increasingly used to assess intracranial arterial stenoocclusion. However, MR angiography can cause overestimation of stenosis. Although CT angiography is accurate, it has limitations. Our purpose was to determine whether the accuracy of combined MR angiography and CT angiography is equal to that of digital subtraction angiography (DSA) in ...

Angiotensin II (Ang II) stimulates vascular inflammation, oxidative stress, and formation and rupture of intracranial aneurysms in mice. Because Ang 1-7 acts on Mas receptors and generally counteracts deleterious effects of Ang II, we tested the hypothesis that Ang 1-7 attenuates formation and rupture of intracranial aneurysms. Intracranial aneurysms were induced in wild-type and Mas receptor-d...

BACKGROUND AND PURPOSE The goal of this study was to document the long-term outcome of ischemic stroke patients in a population with predominant intracranial atherosclerosis and risk factors for a recurrent event. METHODS Intracranial and extracranial arteries of consecutive patients with acute ischemic stroke were studied prospectively with transcranial Doppler and duplex ultrasound. All pat...

The so-called Monro-Kellie doctrine states that with an intact skull, the sum of the volume of the brain plus the cerebrospinal fluid volume plus the intracranial blood volume is constant. Therefore an increase in one should cause a reduction in one or both of the remaining two. The researcher who expressed the doctrine in such a way was indeed Harvey Cushing in 1925, during a lecture in Edinbu...