Diabetes affects 25.8 million people, or 8.3% of the U.S. population. Among people with diabetes, 26% are insulin users.[1] Therapy with insulin is effective at lowering blood glucose in patients with diabetes. Insulin is a key player in the control of diabetes for patients with type 1, and it is required at later stages by patients with type 2. Hyperglycemia in type 1 diabetes is a result of t...

Background: Diabetic ketoacidosis (DKA) is a disorder of carbohydrate metabolism that causes frequent urination, emaciation, extreme tiredness and dehydration. There is little or no information available on DKA in male goat (buck). The present study was carried out to report a rare case of DKA in a buck. Case description: A 1.5 year old buck was presented with ...

That diabetes is associated with an increased lifetime risk of developing malignancy is now well established (1,2). For some specific malignancies, explanation of that increased risk is possible, though usually unproven. For example, the marked increase in pancreatic cancer incidence in type 2 diabetes may or may not be due to misattribution of type of diabetes where the reality is secondary di...

Abstract The occurrence and development of insulin resistance (IR) are usually related to the change gut microbiota. Our previous study showed that arabinogalactan (AG) could selectively increase relative abundance Bifidobacterium longum Faecalibacterium prausnitzii in vitro fermentation. However, their effect on IR remains unclear. In current study, we investigated effects AG, B. longum, F. co...

Vagus nerve stimulation (VNS) therapy was shown to improve peripheral insulin sensitivity. However, the effects of chronic VNS therapy on brain insulin sensitivity, dendritic spine density, brain mitochondrial function, apoptosis and cognition in obese-insulin resistant subjects have never been investigated. Male Wistar rats (n = 24) were fed with either a normal diet (n = 8) or a HFD (n = 16) ...

Aim To determine variables associated with hyperglycemia and insulin therapy in postoperative inpatients with diabetes mellitus following a quality-improvement initiative. Materials & methods Patients with diabetes mellitus following an elective surgical procedure (n = 782; 877 surgical procedures) were selected. Results Age, hemoglobin A1c corticosteroids, insulin therapy and year of surge...

BACKGROUND The course of barriers towards insulin therapy was analysed in three different groups of type 2 diabetic patients. This observational longitudinal study surveyed a three-month follow-up. METHODS Participants in this study totalled 130 type 2 diabetic patients. The first subgroup was on insulin therapy at baseline (group 1: n = 57, age 55.6 ± 8.7 yrs, disease duration 12.7 ± 7.2 yrs...

Concurrent disorders with diabetes mellitus is one of the most challenging subject. Our knowledge of the most common concurrent disorders in diabetic dogs may be useful in diagnosis of these disorders and better treatment of diabetic dogs. In this study diabetes mellitus was diagnosed in a 7-year-old male German shepherd dog, based on clinical and laboratory findings. Following the diagnosis of...

We describe a type 2 diabetic patient who showed immediate-type allergy against human insulin associated with marked eosinophilia at initial insulin therapy. Three months after initiation of insulin therapy, he noticed itchy skin wheals at the site of the insulin injection. Laboratory data at that time showed marked eosinophilia (2512 /mm3) and progression of renal dysfunction. Skin test with s...

A new and simple form of insulin therapy for diabetic hyperglycaemia and ketoacidosis has been developed using a continuous intravenous infusion of insulin at a rate of 2.4 U/hr to maintain serum insulin concentration at physiological levels. This rate raises the mean serum insulin to 83 muU/ml and has a therapeutic effect which is not augmented by higher infusion rates. The response to such lo...