Some of the most spectacular exaggerated sexual ornaments are carotenoid dependent. It has been suggested that such ornaments have evolved because carotenoid pigments are limiting for both signal expression and in their role as antioxidants and immunostimulants. An implicit assumption of this hypothesis is that males which can afford to produce more elaborate carotenoid-dependent displays are s...

An extensive literature suggesting that PRL, GH, IGF-I, and thyroid hormones play an important role in immunity has evolved. Because the use of one or more of these hormones as immunostimulants in humans is being considered, it is of critical importance to resolve their precise role in immunity. This review addresses new experimental evidence from analysis of lymphocyte development and function...

Exosomes are nanovesicles that are released into the extracellular environment during the fusion of multivesicular bodies with the plasma membrane. Exosomes released from dendritic cells, dexosomes, have several biological functions, for example as immunostimulants. Some tumor cells also secrete exosomes (Tu-exosomes). Although experimental data obtained with the use of dexosomes suggest a biol...

The anti-infectious potential of a selection of putative immunostimulants including six commercial beta-glucans (all extracted from baker's yeast Saccharomyces cerevisiae except for Laminarin) and chitin particles were verified in Artemia nauplii by challenging them under gnotobiotic conditions with the pathogen Vibrio campbellii. Under the described experimental conditions, no differential mac...

At the end of 1990s, acute respiratory tract infections (ARTIs) were called the 'forgotten pandemic', with a clear dichotomy between developing and industrialised countries in mortality and morbidity, the main outcomes associated with ARTIs. This definition still applies 20 years later, when the introduction of new and safe antibiotics and vaccines has certainly contributed to controlling the m...

Soybean meal (SBM) is widely used in shrimp feed agro-industry as a fish (FM) replacement. However, high levels of SBM may compromise animal health result nutrient imbalance. This study aimed to investigate the effects enzyme combination (a mixture 6-phytase, serine protease, and endo-1,3(4)-β-glucanase) functional immunostimulant brewer's yeast, nucleotides, vitamin C, E) improving overall Pac...

The formulation of diets from vegetable protein enriched with immunostimulants is a suitable feeding strategy for shrimp culture. This study evaluated feed formulated wheat (Tritium sativum) and chickpea (Cicer arietinum) spirulina (Spirulina maxima) Litopenaeus vannamei farming. A based on (2.5:1) containing 3% was developed characterized by proximal chemical analysis. experimental along comme...

UNLABELLED Preschool children frequently suffer from acute respiratory tract infections (ARTI). Immunostimulants (ISs) are often administered to reduce their impact. This study aimed to establish the efficacy of ISs in the prevention of pediatric ARTI through the analysis of systematic reviews (SRs). We explored Medline database in October 2010 limiting our search to SRs, that included studies ...

Eighty-four patients with advanced cancer refractory to conventional therapeutic modalities were randomly assigned in double-blind fashion to one of three intradermal treatment regimens: "high"-dose methanol extraction residue fraction of Bacillus Calmette-Guérin (MER) (2.0 mg); "low"-dose MER (0.5 mg); or 0.9% NaCl solution placebo. Toxicity, consisting primarily of cutaneous inflammation and ...