T HE use of monoamine oxidase (MAO) inhibitors in the treatment of hypertension has been limited until recently, mainly because the available compounds had a high incidence of accompanying side reactions.' However, the non-hydrazine MAO inhibitor, pargyline, appears to be an effective drug with a relatively low incidence of untoward effects. Clinical studies have substantiated that pargyline is...

throughout the world, millions of muslims fast daily during the month of ramadan from sunrise (sahar) until sunset (iftar). considering the impacts of environment on physiological functions, we performed this study in order to examine the effects of ramadan fasting on some blood parameters of healthy volunteers and hypertensive patients. according to the results, there were no significant chang...

Although effective in maintaining relatively normal levels of blood pressure in hypertensive patients and retarding some of the serious and fatal secondary consequences of the disease, hexamethonium ion and 1-hydrazinophthalazine can cause severe immediate and late reactions. The latter drug has produced collagen diseases of varying degrees of severity, all of which have regressed on cessation ...

Although effective in maintaining relatively normal levels of blood pressure in hypertensive patients and retarding some of the serious and fatal secondary consequences of the disease, hexamethonium ion and 1-hydrazinophthalazine can cause severe immediate and late reactions. The latter drug has produced collagen diseases of varying degrees of severity, all of which have regressed on cessation ...

Rectal potential difference (pd) is directly related to the plasma aldosterone concentration, and rises when aldosterone is stimulated by sodium deprivation. However, when the measurement of rectal pd was tested at a screening test for hyperaldosteronism in 19 hypertensive subjects, four of the eight with primary hyperaldosteronism had a normal pd and four of the eight without aldosterone exces...

Vascular smooth muscle cells (VSMCs) at capacitance arteries of hypertensive individuals and animals undergo marked age- and blood pressure-dependent polyploidization and hypertrophy. We show here that VSMCs at capacitance arteries of rat models of hypertension display high levels of Akt1/PKB protein and activity. Gene transfer of Akt1 to VSMCs isolated from a normotensive rat strain was suffic...

In eight hypertensive patients, forearm vascular tone was assessed by water plethysmography following inhibition of angiotensin II-converting-enzyme (ACE) activity with captopril. Acute captopril administration increased venous distensibility (VV30) and decreased forearm vascular resistance (FVR), while it lowered systemic blood pressure (BP). Alpha-one adrenergic receptor blockade by prazosin ...

Although pentolinium tartrate is widely used in the treatment of hypertension, there are no reports available regarding some of its cardiovascular effects and its influence on water and electrolyte excretion. The results of the present study indicate that this drug is of value in reducing the mean arterial blood pressure in hypertensive patients. However, the data also indicate the necessity fo...

T HE use of monoamine oxidase (MAO) inhibitors in the treatment of hypertension has been limited until recently, mainly because the available compounds had a high incidence of accompanying side reactions.' However, the non-hydrazine MAO inhibitor, pargyline, appears to be an effective drug with a relatively low incidence of untoward effects. Clinical studies have substantiated that pargyline is...

Although pentolinium tartrate is widely used in the treatment of hypertension, there are no reports available regarding some of its cardiovascular effects and its influence on water and electrolyte excretion. The results of the present study indicate that this drug is of value in reducing the mean arterial blood pressure in hypertensive patients. However, the data also indicate the necessity fo...